Turkish Journal of Gastroenterology
Liver - Original Article

Bacteremia in cirrhotic patients with upper gastrointestinal bleeding

1.

Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi County, Taiwan

2.

Department of Emergency, Taichung Tzu Chi Hospital, Taichung City, Taiwan

3.

Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua County, Taiwan

4.

Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi County, Taiwan.; Department of Nursing, Chang Gung University of Science and Technology, Chiayi County, Taiwan.

Turk J Gastroenterol 2018; 29: 164-169
DOI: 10.5152/tjg.2018.17309
Read: 62 Downloads: 5 Published: 25 July 2019

Abstract

 

Background/Aims: Increased risk of bacterial infection is common in cirrhotic patients with upper gastrointestinal bleeding (UGIB). Our study aimed to explore the association of the bacteremia with in-hospital mortality and risk factors of bacteremia in these patients.

 

Materials and Methods: In our retrospective cohort study, we collected data for cirrhotic patients with UGIB admitted to our hospital between August 2010 and December 2010. The primary outcome was in-hospital mortality. The secondary outcome was bacteremia. A multivariate logistic regression analysis was performed to determine risk factors for mortality and bacteremia.

 

Results: A total of 202 patients with cirrhosis presenting with UGIB at the emergency department (ED) were enrolled. Bacteremia was associated with a higher mortality rate (adjusted odds ratio [OR]: 9.7; 95% confidence interval [CI]: 1.9-50.6, p=0.007), whereas shock (systolic blood pressure <90 mmHg at ED triage) and bandemia (>0% immature neutrophils of band form) were associated with bacteremia in cirrhotic patients with UGIB (adjusted OR: 5.3; 95% CI: 2.3-12.7, p<0.0001 and adjusted OR: 4.0; 95% CI: 1.6-9.9, p=0.0003, respectively).

 

Conclusion: Bacteremia in cirrhotic patients with UGIB is one of the major risk factors leading to in-hospital mortality. On the basis of our findings, prevention of bacteremia in cirrhotic patients with UGIB, especially in those with shock and bandemia, is important; thus, adequate antibiotic treatment is suggested.

 

 

 

Cite this article as: Shih HA, Tsai PC, Wu KH, Chen YT, Chen YC. Bacteremia in cirrhotic patients with upper gastrointestinal bleeding. Turk J Gastroenterol 2018; 29: 164-9.

 

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