Turkish Journal of Gastroenterology
Original Article

Association between single nucleotide polymorphisms in prospective genes and susceptibility to ankylosing spondylitis and inflammatory bowel disease in a single centre in Turkey

1.

Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey

2.

Department of Rheumatology, Ankara University School of Medicine, Ankara, Turkey

3.

Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey

4.

Department of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey

5.

Department of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey

6.

Department of Physical Medicine and Rehabilitation, Mustafa Kemal University School of Medicine, Hatay, Turkey

7.

Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey

Turk J Gastroenterol 2016; 27: 317-324
DOI: 10.5152/tjg.2016.15466
Read: 575 Downloads: 103 Published: 25 July 2019

Abstract

Background/Aims: To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2) in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) in a Turkish population.

 

Materials and Methods: A total of 562 subjects who presented at the Ankara University internal medicine departments of rheumatology and gastroenterology outpatient clinics were recruited in this study, including 365 patients with AS, 197 patients with IBD and 230 healthy controls. ERAP1, IL-23R, STAT-3 and JAK-2) were genotyped in competitive allele-specific polymerase chain reactions.

 

Results: The ERAP1 (rs26653) polymorphism was found to increase the disease risk in patients with AS and IBD compared with the control group (p=0.02 and p=0.01, respectively). In addition, this polymorphism revealed a significant relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI) in patients with AS (r=0.829, p<0.001 and r=0.731, p<0.001, respectively).

 

Conclusion: The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of AS and IBD. In contrast, IL-23R gene polymorphisms may serve a protective role in AS and IBD.

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