Turkish Journal of Gastroenterology
Liver - Original Article

Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?


Division of Gastroenterology, Department of Internal Medicine, Necmettin Erbakan University, Meram School of Medicine, Meram, Konya, Turkey


Division of Gastroenterology, Department of Internal Medicine, Van Training and Research Hospital, Van, Turkey


Department of Medical Genetics, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey

Turk J Gastroenterol 2021; 32: 593-599
DOI: 10.5152/tjg.2021.20657
Read: 791 Downloads: 294 Published: 01 July 2021

Background: Hepatocellular carcinoma (HCC) is one of the important causes of mortality due to malignancy. Toll-like receptors (TLRs) are very important in liver pathophysiology in terms of their roles in the innate immune system, such as the regulation of inflammation, wound healing, stimulation of adaptive immune responses, promotion of epithelial regeneration, and carcinogenesis. In this study, we planned to examine the role of TLR1 (rs4833095, rs5743551) and nucleotide-binding oligomerization domain (NOD2) (rs2066844, rs2066845, rs2066847) polymorphisms in the development of HCC and their effects on the clinical presentation of HCC patients.

Methods: Our study was designed prospectively. Cirrhotic and HCC patients who were followed up in our clinic between January 2015 and September 2018 were included in the study. Sex, age, cirrhosis etiology, Child–Pugh class, and MELD scores were recorded. TLR1 and NOD2 polymorphisms were studied by the PCR method.

Results: HCC developed in 88 (31.4%) of the 280 patients who were followed up, either during the recruitment phase of our study or during the follow-up. The mean follow-up time of our patient group was 17.04 ± 11.72 months, and the mean follow-up time of HCC patients was 12.09 ± 10.26 months. TLR1 (rs5743551) polymorphism was associated with HCC development (P = .003). TLR1 (rs5743551) and NOD2 (rs2066844) polymorphisms were associated with the development of spontaneous bacterial peritonitis (SBP) in the HCC patient group (P = .013 and P = .021, respectively).

Conclusion: We think that increased bacterial translocation in cirrhotic patients may contribute to HCC development by causing chronic inflammation, especially in patients with TLR 1 (rs5743551) polymorphism.

Cite this article as: Dertli R, Asil M, Bıyık M, et al. Are pattern recognition receptors associated with Hepatocellular carcinoma? Turk J Gastroenterol. 2021; 32(7): 593-599.

EISSN 2148-5607