Turkish Journal of Gastroenterology
Original Article

18F-FDG activitiy PET/CT and CA-19.9 levels for the prediction of histopathological features and localization of peri- ampullary tumors


Department of General Surgery, Çukurova University Faculty of Pharmacy, Adana, Turkey


Department of Nuclear Medicine, Çukurova University Faculty of Medicine, Adana, Turkey


Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey


Department of General Surgery, Ankara University Faculty of Medicine, Ankara , Turkey

Turk J Gastroenterol 2015; 26: 170-175
DOI: 10.5152/tjg.2015.7870
Read: 1225 Downloads: 515 Published: 25 July 2019


Background/Aims: We sought to investigate the roles of maximum standardized uptake value (SUVmax) and serum carbohydrate antigen 19-9 (CA 19-9) in predicting the histopathological features of periampullary tumors.


Materials and Methods: Thirty-four patients with histologically confirmed periampullary tumors were classified into two groups, according to the localizations of their tumors (ampulla Vateri or pancreas). SUVmax was obtained from [(18)F]-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT). SUVmax and CA 19-9 levels were measured and compared with histopathological features of the tumors. Logistic regression was used to assess the significance and independence of predictive factors.


Results: 18F-FDG PET/CT SUVmax (<2.5 vs. ≥2.5; p=0.031) and CA 19-9 level (normal vs. elevated; p=0.045) were significantly and independently predictive of the histopathological origin of the tumors (ampulla Vateri vs. pancreas). The ratio of CA 19-9 levels and SUVmax were found to be higher in cases of poorly differentiated tumors and tumors greater than 2 cm in diameter.



Conclusion: A surgical approach to treatment may be considered for patients who have both i) an established or suspected diagnosis of periampullary tumors and ii) low SUVmax and CA 19-9 levels.

EISSN 2148-5607