Published In
Turkish Journal of Gastroenterology
Volume 37 · Issue 8
Pages: 824-838
History
Published Online: June 19, 2026
This work is licensed under a Creative Commons Attribution 4.0 International License.
Victoria E. Abadi-Ron
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Ana Marenco-Flores
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Natalia Rojas-Amaris
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Fernando Munguía
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Javier Polo-Ibarra
Department of Emergency Medicine, Boston Medical Center, Boston University, Boston, USA
Behnam Saberi
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Vilas R. Patwardhan
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Alan Bonder
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Abadi-Ron, V. E., Marenco-Flores, A., Rojas-Amaris, N., Munguía, F., Polo-Ibarra, J., Saberi, B., … Bonder, A. (2026). Current Treatment of Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Comprehensive Review. Turkish Journal of Gastroenterology, 37(8), 824–838. https://doi.org/10.5152/tjg.2026.26267
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Abstract
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are chronic cholestatic liver diseases characterized by bile duct injury that may progress to fibrosis, cirrhosis, liver failure, and malignancy and ultimately require liver transplantation. Although these diseases share several clinical features, they differ substantially in pathogenesis, clinical course, and therapeutic approaches. Ursodeoxycholic acid remains the standard first-line therapy for PBC; patients with an inadequate biochemical response may be treated with second-line agents such as seladelpar, elafibranor, or fibrates. In contrast, no approved therapy has been shown to slow disease progression in PSC. Emerging therapies primarily target symptom and complication management, and overall management focuses on surveillance and timely referral for liver transplantation. This review summarizes current approaches to risk assessment, treatment, symptom management, monitoring, and transplantation decision-making in both conditions.
Cite this article as: Abadi-Ron V, Marenco-Flores A, Rojas-Amaris N, et al. Current treatment of primary biliary cholangitis and primary sclerosing cholangitis: A comprehensive review. Turk J Gastroenterol. 2026;37(8):824-838.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 37 · Issue 8
Pages
824-838
History
Published Online
June 19, 2026
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Affiliations
Victoria E. Abadi-Ron
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Ana Marenco-Flores
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Natalia Rojas-Amaris
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Fernando Munguía
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Javier Polo-Ibarra
Department of Emergency Medicine, Boston Medical Center, Boston University, Boston, USA
Behnam Saberi
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Vilas R. Patwardhan
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Alan Bonder
Division of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Cite this Article
Abadi-Ron, V. E., Marenco-Flores, A., Rojas-Amaris, N., Munguía, F., Polo-Ibarra, J., Saberi, B., … Bonder, A. (2026). Current Treatment of Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Comprehensive Review. Turkish Journal of Gastroenterology, 37(8), 824–838. https://doi.org/10.5152/tjg.2026.26267
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