Abstract
Pancreatic exocrine insufficiency (PEI) is characterized by inadequate synthesis, secretion, and/or activation of exocrine pancreatic secretions. This guideline has been developed to assist clinicians and researchers in understanding the definition, etiopathogenesis, epidemiology, diagnosis, treatment, and follow-up of PEI based on the current literature. All statements within this review were developed through consensus among the authors based on a comprehensive literature review.
Cite this article as: Sezgin O, Oğuz D, Soytürk M, Kalkan İH, Bengi G, Gül Ö. Clinical practice update on the evaluation, diagnosis, and management of pancreatic exocrine insufficiency: Expert review. Turk J Gastroenterol. 2026;37(5):534-554.
Most read articles by the same author(s)
- Zekiye Nur Harput, Orhan Sezgin, Feramuz Demir Apaydın, Enver Reyhan, Abdominal Cocoon Syndrome: A Rare Condition That Causes Diagnostic Challenges , Turkish Journal of Gastroenterology: Vol. 37 No. 7 (2026): Turkish Journal of Gastroenterology
- Levent Erdem, Erdem Akbal, Erdem Koçak, Dilek Tucer, Enver Üçbilek, Ahmet Uyanıkoğlu, Can Dolapçıoğlu, Emel Ahısalı Erim, Göktuğ Şirin, Hüseyin Alkım, Aliye Soylu, Levent Doğanay, Ahmet Kemal Kürbüz, Kamil Özdil, Hakan Alagözlü, Tuba Erürker Öztürk, Mesut Sezikli, Gupse Adalı, Mehmet Çoban, Saadettin Hülagü, Halil Değertekin, Alp Atasoy, Filiz Akyüz, İlham Gaffarlı, Murat Saruç, Engin Altıntaş, Orhan Sezgin, Nurdan Tözün, A New Risk-Scoring System for Colorectal Cancer and Polyp Screening by Turkish Colorectal Cancer and Polyp Study Group , Turkish Journal of Gastroenterology: Vol. 33 No. 4 (2022): Turkish Journal of Gastroenterology
- Filiz Akyüz, Altay Çelebi, İbrahim Doğan, Yusuf Erzin, Taylan Kav, Müjde Soytürk, Dilek Oğuz, Birol Özer, Sabahattin Kaymakoğlu, Functional Bowel Disorder Management in Routine Practice with Tips for Hot Topics: Expert Opinion Review , Turkish Journal of Gastroenterology: Vol. 35 No. 6 (2024): Turkish Journal of Gastroenterology
- Dilek OĞUZ, Yıldıran SONGÜR, Orhan SEZGİN, Gönül GÜRKAYNAK, Uğur YILMAZ, Ahmet TEZEL, Ülkü SARITAŞ, Burhan ŞAHİN, Endoscopic management of chronic pancreatitis: Pancreatic stents , Turkish Journal of Gastroenterology: Vol. 10 No. 4 (1999): Turkish Journal of Gastroenterology
- Ulus Salih Akarca, Belkis Unsal, Orhan Sezgin, Kendal Yalcin, Meral Akdogan, Can Gonen, Feyza Gunduz, Seren Ozenirler, Abdullah Sonsuz, Dinc Dincer, Salim Basol Tekin, Idris Yucel, Hakan Akbulut, Canan Alkım, Ozgur Ozyilkan, Arzu Baygul, Zeynep Merve Cevik, Ramazan Idilman, Characteristics of Newly Diagnosed Hepatocellular Carcinoma Patients Across Turkey: Prospective Multicenter Observational 3K Registry Study , Turkish Journal of Gastroenterology: Vol. 32 No. 12 (2021): Turkish Journal of Gastroenterology
- Orhan Sezgin, Hale Akpınar, Birol Özer, Murat Törüner, Kadir Bal, Serhat Bor, The Abdominal Ultrasonography Results of Cappadocia Cohort Study of Turkey Reveals High Prevalence of Fatty Liver , Turkish Journal of Gastroenterology: Vol. 34 No. 6 (2023): Turkish Journal of Gastroenterology
- Pinar Cirit Yilmaz, Orhan Sezgin, Systemic Immune-Inflammation Index and Selected Immune-Based Scores in the Diagnosis and Monitoring of Celiac Disease , Turkish Journal of Gastroenterology: Vol. 37 No. 5 (2026): Turkish Journal of Gastroenterology
- Orhan Sezgin, Hale Akpınar, Birol Özer, Murat Törüner, Kadir Bal, Serhat Bor, Population-based assessment of gastrointestinal symptoms and diseases: Cappadocia Cohort, Turkey , Turkish Journal of Gastroenterology: Vol. 30 No. 12 (2019): Turkish Journal of Gastroenterology
- Orhan Sezgin, Mehmet Kasım Aydın, Asena Ayça Özdemir, Arzu Emine Kanık, Standard triple therapy in Helicobacter pylori eradication in Turkey: Systematic evaluation and meta-analysis of 10-year studies , Turkish Journal of Gastroenterology: Vol. 30 No. 5 (2019): Turkish Journal of Gastroenterology
- Emin ALTIPARMAK, Çağlar BAYSAL, Orhan SEZGİN, Erkan PARLAK, Burhan ŞAHİN, Addition of cisapride to standart colon cleansing for colonoscopy , Turkish Journal of Gastroenterology: Vol. 9 No. 4 (1998): Turkish Journal of Gastroenterology

This work is licensed under a Creative Commons Attribution 4.0 International License.