Published In
Turkish Journal of Gastroenterology
Volume 30 · Issue Supplement 1
Pages: 36-36
History
Published Online: July 25, 2019
Copyright © 2019 Mehmet Demir
Mehmet Demir
Department of Gastroenterology Mustafa Kemal University Hatay Turkey
Demir, M. (2019). Efficacy of entecavir treatment for up to 5 years in patients with HBV-related compensated cirrhosis in Turkey; real life data. Turkish Journal of Gastroenterology, 30(Supplement 1), 36–36. https://doi.org/10.5152/tjg.2019.22
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Abstract
INTRODUCTION: The aim of this study was to determine the efficacy and safety of long term entecavir monotherapy in patients with HBV-related compensated cirrhosis(HBV-RC) in Turkey.
METHODS: We performed a retrospective analysis of data from 102 adult patients with HBV-RC, beginning in 2013,at single center throughout Turkey. Baseline demographic characteristics, laboratory and clinical outcomes were recorded at yearly intervals. Patients with cirrhosis, hepatocellular carcinoma, pregnant or in lactation, and co-infected with hepatitis C, D or human immunodeficiency virus were excluded. Baseline liver biopsy was performed in 56% of the patients.
RESULTS: In this study, 102 HBV-RC patients receiving entecavir therapy were included. Average age was 48±7 years, 100% of patients were naive, 21% of patients were HBeAg positive and 55% were male. Mean follow-up was 32 ±13 months. Mean histopathologic activity index were 14 and fibrosis scores were 5.5 (according to ishak score). Baseline mean ALT and HBV DNA levels were 65 U/L and 4.3 log10 copies/mL, respectively. At the end of the 1st,2nd,3rd,4th, and 5th years of therapy, HBV DNA
CONCLUSION: Entecavir is effective and safe for long-term use in patients with HBV-related compensated cirrhosis in Turkey.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 30 · Issue Supplement 1
Pages
36-36
History
Published Online
July 25, 2019
Copyright
Copyright (c) 2019 Mehmet Demir
Affiliations
Mehmet Demir
Department of Gastroenterology Mustafa Kemal University Hatay Turkey
Cite this Article
Demir, M. (2019). Efficacy of entecavir treatment for up to 5 years in patients with HBV-related compensated cirrhosis in Turkey; real life data. Turkish Journal of Gastroenterology, 30(Supplement 1), 36–36. https://doi.org/10.5152/tjg.2019.22
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