Prevalence of Helicobacter pylori Infection in Geriatric Adults: A Single-Center Cohort Study from Türkiye

Abstract

Background/Aims: Helicobacter pylori infection remains an important global health issue, particularly among older adults for whom related complications are more frequent. However, epidemiological data on the elderly populations in Türkiye are limited. This study aimed to determine the prevalence, associated factors, and endoscopic–histopathological correlations of H. pylori infection in a large geriatric cohort.

Materials and Methods: This single-center retrospective study included 2000 adults aged ≥65 years who underwent esophagogastro duodenoscopy between January 2023 and December 2024. Active infection was determined by stool antigen testing according to the Updated Sydney System. Demographic, clinical, endoscopic, and histopathological parameters were analyzed, and independent predic tors were identified using multivariate logistic regression.

Results: The mean age of the participants was 77.5 ± 7.8 years, and 50.2% were male. The overall prevalence of H. pylori infections was 56.3%. Prior eradication therapy was independently protective (31.3% vs. 66.1%; P < .001). Infection rates did not differ significantly according to sex, smoking, alcohol use, or comorbidities. The highest positivity rates were observed for atrophic gastritis (60.8%), pan gastritis (58.0%), and antral gastritis (56.2%). The prevalence declined modestly in the oldest-old group (≥85 years), whereas atrophic and metaplastic changes increased with age.

Conclusion: Helicobacter pylori infection remains highly prevalent among elderly individuals in Türkiye, showing a gradual decline com pared with historical national data but a persistent association with premalignant mucosal changes. Early detection and individualized eradication strategies are essential to optimize geriatric gastrointestinal care.

Cite this article as: Özden Y, Bulur O. Prevalence of Helicobacter pylori infection in geriatric adults: a single-center cohort study from Türkiye. Turk J Gastroenterol. Published online January 5, 2026. doi: 10.5152/tjg.2025.25499.