Published In
Turkish Journal of Gastroenterology
Volume 37 · Issue 3
Pages: 301-309
History
Published Online: October 22, 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright © 2025 Kadir Demir, Aslı Çifcibaşı Örmeci, Bilger Çavuş, Zülal İstemihan, Sezen Genç, Alp Atasoy, Filiz Akyüz, Fatih Beşışık, Sabahattin Kaymakoğlu
Kadir Demir
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Aslı Çifcibaşı Örmeci
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Bilger Çavuş
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Zülal İstemihan
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sezen Genç
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Alp Atasoy
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Filiz Akyüz
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Fatih Beşışık
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sabahattin Kaymakoğlu
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Demir, K., Çifcibaşı Örmeci, A., Çavuş, B., İstemihan, Z., Genç, S., Atasoy, A., … Kaymakoğlu, S. (2025). Maternal and Fetal Outcomes of Pregnancies in Wilson’s Disease: A Single-Centre Real-Life Experience. Turkish Journal of Gastroenterology, 37(3), 301–309. https://doi.org/10.5152/tjg.2025.25448
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Abstract
Background/Aims: This study aims to investigate the fetal outcomes and pregnancy course in patients with Wilson’s disease (WD).
Materials and Methods: A total of 54 female patients with a diagnosis of WD and a history of pregnancy between 1985 and 2021 were retrospectively examined in a specifically WD outpatient clinic in the İstanbul Faculty of Medicine.
Results: A total of 131 pregnancies in 54 patients were examined. The mean age at diagnosis of WD was 22.1 ± 10.8 years. The mean follow-up period of patients diagnosed with WD was 87 ± 80 months. Forty (74.1%) patients were diagnosed with hepatic, 5 (9.3%) neurological, and 9 (16.6%) with mixed involvement WD. The liver was cirrhotic in 68 (51.9%) pregnancies. Ninety-eight (74.8%) preg nancies resulted in live birth, 30 spontaneous abortions (22.9%), and 3 (2.3%) stillbirths. Pregnancies diagnosed with mixed pattern WD had a lower live birth rate than those diagnosed with WD with isolated hepatic or neurological involvement (P < .001 and P = .004, respectively). While the spontaneous abortion rate decreases with WD treatment, the rate of live birth, stillbirth, premature birth, and low birth weight did not change in the total group. During pregnancy, patients used D-penicillamine, trientine, and/or zinc.
Conclusion: With careful monitoring and management by medical professionals, pregnant women diagnosed with WD can still achieve successful pregnancies and improve their quality of life.
Cite this article as: Demir K, Örmeci AÇ, Çavuş B, et al. Maternal and fetal outcomes of pregnancies in Wilson’s disease: A singlecentre real-life experience. Turk J Gastroenterol. 2026;37(3):301-309.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 37 · Issue 3
Pages
301-309
History
Published Online
October 22, 2025
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright
Copyright (c) 2025 Kadir Demir, Aslı Çifcibaşı Örmeci, Bilger Çavuş, Zülal İstemihan, Sezen Genç, Alp Atasoy, Filiz Akyüz, Fatih Beşışık, Sabahattin Kaymakoğlu
Affiliations
Kadir Demir
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Aslı Çifcibaşı Örmeci
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Bilger Çavuş
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Zülal İstemihan
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sezen Genç
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Alp Atasoy
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Filiz Akyüz
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Fatih Beşışık
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Sabahattin Kaymakoğlu
Division of Gastroenterohepatology, Department of Internal Medicine, İstanbul University İstanbul Faculty of Medicine, İstanbul, Türkiye
Cite this Article
Demir, K., Çifcibaşı Örmeci, A., Çavuş, B., İstemihan, Z., Genç, S., Atasoy, A., … Kaymakoğlu, S. (2025). Maternal and Fetal Outcomes of Pregnancies in Wilson’s Disease: A Single-Centre Real-Life Experience. Turkish Journal of Gastroenterology, 37(3), 301–309. https://doi.org/10.5152/tjg.2025.25448
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