Original Article

Neutrophil-Lymphocyte Ratio and LDH/Albumin Ratio as Biomarkers for Severity and Mortality in Acute Pancreatitis

Volume 36 · Issue 8 Publish Date: June 16, 2025
Göksel Bengi ORCID İbrahim Çelik ORCID Süleyman Dolu ORCID Soner Önem ORCID Müjde Soytürk ORCID Serkan Rendeci ORCID Ömer Topalak ORCID Hale Akpinar ORCID
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Turkish Journal of Gastroenterology

Volume 36 · Issue 8

Pages: 497-507

History

Published Online: June 16, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Göksel Bengi, İbrahim Çelik, Süleyman Dolu, Soner Önem, Müjde Soytürk, Serkan Rendeci, Ömer Topalak, Hale Akpinar

Göksel Bengi ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
İbrahim Çelik ORCID
Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Süleyman Dolu ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Soner Önem ORCID
Department of Gastroenterology, Samsun Training and Research Hospital, Samsun, Türkiye
Müjde Soytürk ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Serkan Rendeci ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ömer Topalak ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Hale Akpinar ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Bengi, G., Çelik, İbrahim, Dolu, S., Önem, S., Soytürk, M., Rendeci, S., … Akpinar, H. (2025). Neutrophil-Lymphocyte Ratio and LDH/Albumin Ratio as Biomarkers for Severity and Mortality in Acute Pancreatitis. Turkish Journal of Gastroenterology, 36(8), 497–507. https://doi.org/10.5152/tjg.2025.24828
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Abstract

Background/Aims: Acute pancreatitis (AP) is a common and potentially severe condition, and early identification of its severity is critical for appropriate clinical management. This study aimed to investigate the role of the Neutrophil-Lymphocyte Ratio (NLR) and Lactate dehydrogenase (LDH)/Albumin Ratio (LAR) in predicting the severity and prognosis of patients with AP and to determine the optimal NLR value.

Materials and Methods: The demographic, clinical, and laboratory data of patients diagnosed with AP were retrospectively analyzed. Neutrophil-Lymphocyte Ratio was measured at admission (0 hours), and at 24 and 48 hours; C-reactive protein (CRP) values were recorded at 0 and 48 hours; and the LAR was calculated based on LDH and albumin values measured at 48 hours post admission. These values were compared with disease severity, mortality, organ failure, length of hospital stay, and the need for intensive care according to Ranson and bedside index of severity in AP (BISAP) scores.

Results: According to the BISAP scoring, 38 patients (16%) were classified as having severe AP, while 200 patients (84%) had mild AP. The best parameter for predicting severe AP was found to be the 24-hour NLR with a sensitivity of 79% and specificity of 67%. The best parameter for predicting mortality and organ failure was the NLR at 48 hours. There was a statistically significant difference between the length of hospital stay and the need for intensive care with the CRP value at 48 hours. Additionally, there was a statistically signifi cant relationship between LAR and mortality, length of hospital stay, organ failure, and the need for intensive care.

Conclusion: This study demonstrates that the NLR and the LDH/Albumin Ratio are important and easily accessible markers for deter
mining the severity and prognosis of AP. The NLR at 48 hours is an effective parameter for predicting mortality and organ failure, while the LDH/Albumin Ratio is significant in predicting mortality.

 

Cite this article as: Bengi G, Çelik İ, Dolu S, et al. Neutrophil-lymphocyte ratio and LDH/albumin ratio as biomarkers for severity and mortality in acute pancreatitis. Turk J Gastroenterol. 2025;36(8):497-507.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 8
Pages 497-507
DOI 10.5152/tjg.2025.24828
History
Published Online June 16, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Göksel Bengi, İbrahim Çelik, Süleyman Dolu, Soner Önem, Müjde Soytürk, Serkan Rendeci, Ömer Topalak, Hale Akpinar
Affiliations
Göksel Bengi ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
İbrahim Çelik ORCID
Department of Internal Medicine, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Süleyman Dolu ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Soner Önem ORCID
Department of Gastroenterology, Samsun Training and Research Hospital, Samsun, Türkiye
Müjde Soytürk ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Serkan Rendeci ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Ömer Topalak ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Hale Akpinar ORCID
Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Cite this Article
Bengi, G., Çelik, İbrahim, Dolu, S., Önem, S., Soytürk, M., Rendeci, S., … Akpinar, H. (2025). Neutrophil-Lymphocyte Ratio and LDH/Albumin Ratio as Biomarkers for Severity and Mortality in Acute Pancreatitis. Turkish Journal of Gastroenterology, 36(8), 497–507. https://doi.org/10.5152/tjg.2025.24828
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