Invited Review

Unraveling the Mysteries of Autoimmune Gastritis

Volume 36 · Issue 3 Publish Date: November 25, 2024
İrfan Soykan ORCID Ramazan Erdem Er Yigit Baykara Cağdaş Kalkan ORCID
Full Text PDF
DOI

Published In

Turkish Journal of Gastroenterology

Volume 36 · Issue 3

Pages: 135-144

History

Published Online: November 25, 2024

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2024 İrfan Soykan, Ramazan Erdem Er, Yigit Baykara, Cağdaş Kalkan

İrfan Soykan ORCID
Ankara University Medical School, İbn-i Sina Hospital, Gastroenterology, Ankara, Türkiye
Ramazan Erdem Er
Ankara University Medical School, İbn-i Sina Hospital, Gastroenterology, Ankara, Türkiye
Yigit Baykara
Department of Pathology, Stanford Medicine, Transfusion Medicine and Blood Banking, California, USA
Cağdaş Kalkan ORCID
Department of Gastroenterology, Ministry of Health, Bilkent City Hospital, Çankaya, Ankara, Türkiye
Soykan, İrfan, Er, R. E., Baykara, Y., & Kalkan, C. (2024). Unraveling the Mysteries of Autoimmune Gastritis. Turkish Journal of Gastroenterology, 36(3), 135–144. https://doi.org/10.5152/tjg.2024.24563
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text FULL TEXT PDF

Abstract

Autoimmune gastritis is an immune-mediated disease characterized by the destruction of parietal cells and atrophy of the oxyntic mucosa due to anti-parietal cell antibodies. It may lead to serious conditions including iron/vitamin B12 and micronutrient deficiencies, neurological disorders, and gastric malignancies. The exact mechanism of this disease is not exactly understood; however, dysregu lated immunological mechanisms appear to be major contributors. Patients with this disease are often asymptomatic but may present with gastrointestinal symptoms and/or iron/vitamin B12 deficiencies. Although important serological markers are available and despite advanced endoscopic techniques, the definitive diagnosis relies on histopathological examination of gastric corporal biopsy specimens. Autoimmune gastritis is closely related with increased risk of gastric neuroendocrine tumors and gastric adenocarcinoma. Patients with autoimmune gastritis do not benefit from specific treatments, thus, management is directed to restore micronutrient deficiencies and to prevent occurrence of neoplastic transformation with appropriate endoscopic surveillance.

 

Cite this article as: Soykan İ, Er RE, Baykara Y, Kalkan C. Unraveling the mysteries of autoimmune gastritis. Turk J Gastroenterol. 2025;36(3):135-144.

Most read articles by the same author(s)

<< < 1 2 3 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 3
Pages 135-144
DOI 10.5152/tjg.2024.24563
History
Published Online November 25, 2024
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2024 İrfan Soykan, Ramazan Erdem Er, Yigit Baykara, Cağdaş Kalkan
Affiliations
İrfan Soykan ORCID
Ankara University Medical School, İbn-i Sina Hospital, Gastroenterology, Ankara, Türkiye
Ramazan Erdem Er
Ankara University Medical School, İbn-i Sina Hospital, Gastroenterology, Ankara, Türkiye
Yigit Baykara
Department of Pathology, Stanford Medicine, Transfusion Medicine and Blood Banking, California, USA
Cağdaş Kalkan ORCID
Department of Gastroenterology, Ministry of Health, Bilkent City Hospital, Çankaya, Ankara, Türkiye
Cite this Article
Soykan, İrfan, Er, R. E., Baykara, Y., & Kalkan, C. (2024). Unraveling the Mysteries of Autoimmune Gastritis. Turkish Journal of Gastroenterology, 36(3), 135–144. https://doi.org/10.5152/tjg.2024.24563
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines