Original Article

Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning

Volume 36 · Issue 2 Publish Date: December 18, 2025
Hayri Canbaz ORCID Attila Bestemir ORCID Sami Akbulut ORCID Sezai Yilmaz ORCID Yusuf Yavuz ORCID
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Turkish Journal of Gastroenterology

Volume 36 · Issue 2

Pages: 107-113

History

Published Online: December 18, 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2025 Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

Hayri Canbaz ORCID
Department of Emergency Medicine, Yıldırım Beyazit University, Yenimahalle Training and Research Hospital, Ankara, Türkiye
Attila Bestemir ORCID
Department of Private Health Institutions with Outpatient Diagnosis and Treatment, Ministry of Health, Ankara, Türkiye
Sami Akbulut ORCID
Department of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, Türkiye
Sezai Yilmaz ORCID
Department of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, Türkiye
Yusuf Yavuz ORCID
Department of General Surgery, Necmettin Erbakan Universitesi Meram Faculty of Medicine, Konya, Türkiye
Canbaz, H., Bestemir, A., Akbulut, S., Yilmaz, S., & Yavuz, Y. (2025). Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning. Turkish Journal of Gastroenterology, 36(2), 107–113. https://doi.org/10.5152/tjg.2024.24226
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Abstract

Background/Aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning.

Materials and Methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed.

Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. The patients were divided into two groups: alive (n = 18) and dead (n = 8). No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). On the other hand, there were statistically significant differences between the alive and dead groups in terms of MELD score (P = .016; 23 vs. 34), re-transplantation (P = .022; 0% vs. 37.5%), hospital stay (P = .004; 24 vs. 6 days), and follow up (P < .001; 3423 vs. 5 days).

Conclusions: This study showed that mortality was higher in patients with high MELD scores and patients who underwent re-transplantation. However, this study needs to be supported by multicenter prospective studies.

Cite this article as: Canbaz H, Bestemir A, Akbulut S, Yilmaz S, Yavuz Y. Liver  transplantation for acute liver failure due to mushroom poisoning. Turk J Gastroenterol. 2025;36(2):107-113.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 36 · Issue 2
Pages 107-113
DOI 10.5152/tjg.2024.24226
History
Published Online December 18, 2025
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2025 Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz
Affiliations
Hayri Canbaz ORCID
Department of Emergency Medicine, Yıldırım Beyazit University, Yenimahalle Training and Research Hospital, Ankara, Türkiye
Attila Bestemir ORCID
Department of Private Health Institutions with Outpatient Diagnosis and Treatment, Ministry of Health, Ankara, Türkiye
Sami Akbulut ORCID
Department of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, Türkiye
Sezai Yilmaz ORCID
Department of Surgery and Liver Transplant Institute, İnonu University Faculty of Medicine, Malatya, Türkiye
Yusuf Yavuz ORCID
Department of General Surgery, Necmettin Erbakan Universitesi Meram Faculty of Medicine, Konya, Türkiye
Cite this Article
Canbaz, H., Bestemir, A., Akbulut, S., Yilmaz, S., & Yavuz, Y. (2025). Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning. Turkish Journal of Gastroenterology, 36(2), 107–113. https://doi.org/10.5152/tjg.2024.24226
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