Original Article

Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies

Volume 33 · Issue 9 Publish Date: September 15, 2022
Mukaddes Tozlu Gamze Dilek Mehtap Kalçık Unan Ayhan Kamanlı İbrahim Tekeoğlu Mustafa İhsan Uslan Kemal Nas
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Turkish Journal of Gastroenterology

Volume 33 · Issue 9

Pages: 751-759

History

Published Online: September 15, 2022

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2022 Mukaddes Tozlu, Gamze Dilek, Mehtap Kalçık Unan, Ayhan Kamanlı, İbrahim Tekeoğlu, Mustafa İhsan Uslan, Kemal Nas

Mukaddes Tozlu
Department of Gastroenterology, Bezmialem Vakif University Medical School, İstanbul, Turkey
Gamze Dilek
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Mehtap Kalçık Unan
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Ayhan Kamanlı
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
İbrahim Tekeoğlu
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Mustafa İhsan Uslan
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Kemal Nas
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Tozlu, M., Dilek, G., Kalçık Unan, M., Kamanlı, A., Tekeoğlu, İbrahim, Uslan, M. İhsan, & Nas, K. (2022). Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies. Turkish Journal of Gastroenterology, 33(9), 751–759. https://doi.org/10.5152/tjg.2022.22181
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Abstract

Background: We aimed to determine the clinical features, predictive factors associated with severe disease, and outcomes of coronavirus disease 2019 in patients with immune-mediated inflammatory diseases and report data on the comparison of coronavirus disease 2019 between patients with inflammatory bowel disease and spondyloarthropathies. Methods: A total of 101 patients with inflammatory bowel disease and spondyloarthropathies who had confirmed diagnosis of coronavirus disease 2019 were retrospectively analyzed. Demographics, comorbidities, immunosuppressive treatments, and the impact of immunosuppression on negative outcomes were assessed. Results: The median age of the patients was 47 (38-57) years. The most common rheumatologic diagnosis was ankylosing spondylitis (n = 24), psoriatic arthritis (n = 17), and reactive arthritis (n = 1). In the inflammatory bowel disease group, 47 patients had ulcerative colitis, 11 Crohn’s disease, and 1 unclassified. The most commonly used treatments were biologics (55%) in the spondyloarthropathies group and aminosalicylates (66.1%) in the inflammatory bowel disease group. Overall, 18.8% of the patients required hospitalization, 5% developed severe complications, and 2% died. There were no significant differences in coronavirus disease 2019-related negative outcomes between spondyloarthropathies and inflammatory bowel disease patients. The median age was higher in the patients who required hospitalization [57 (46-66) vs 47 (38-57) years, P=.008]. Bilateral opacities on chest radiographs were more common in the patients who required hospitalization in the spondyloarthropathies group [88.9% vs 14.3%, P=.016]. Comorbidity was significantly associated with hospitalization in the inflammatory bowel disease group (P ≤ .05). Baseline therapy with biologics or immunosuppressives was not associated with severe coronavirus disease 2019 outcomes. Conclusion: Older age, comorbidities, and bilateral ground-glass opacities were associated with adverse outcomes, whereas specific immune-mediated inflammatory disease diagnoses or immunosuppressive treatments were not. Cite this article as: Tozlu M, Dilek G, Kalçık Unan M, et al. Clinical features and outcomes of coronavirus disease 2019 in patients with inflammatory bowel disease and spondyloarthropathies. Turk J Gastroenterol. 2022;33(9):751-759.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 9
Pages 751-759
DOI 10.5152/tjg.2022.22181
History
Published Online September 15, 2022
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2022 Mukaddes Tozlu, Gamze Dilek, Mehtap Kalçık Unan, Ayhan Kamanlı, İbrahim Tekeoğlu, Mustafa İhsan Uslan, Kemal Nas
Affiliations
Mukaddes Tozlu
Department of Gastroenterology, Bezmialem Vakif University Medical School, İstanbul, Turkey
Gamze Dilek
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Mehtap Kalçık Unan
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Ayhan Kamanlı
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
İbrahim Tekeoğlu
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Mustafa İhsan Uslan
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Kemal Nas
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, Turkey
Cite this Article
Tozlu, M., Dilek, G., Kalçık Unan, M., Kamanlı, A., Tekeoğlu, İbrahim, Uslan, M. İhsan, & Nas, K. (2022). Clinical Features and Outcomes of Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease and Spondyloarthropathies. Turkish Journal of Gastroenterology, 33(9), 751–759. https://doi.org/10.5152/tjg.2022.22181
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