Original Article

Prevalence and Determinants of Gastrointestinal Manifestations in Patients with Selected Rheumatologic Diseases

Volume 33 · Issue 7 Publish Date: July 15, 2022
Emra Asfuroğlu Kalkan Çağdaş Kalkan Sezgin Barutcu Orhan Küçükşahin Özge Güçbey Tankut Köseoğlu Ateş Şendil Mevlüt Hamamcı Ersan Özaslan İhsan Ateş Emin Altıparmak İrfan Soykan
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DOI

Published In

Turkish Journal of Gastroenterology

Volume 33 · Issue 7

Pages: 576-586

History

Published Online: July 15, 2022

Copyright © 2022 Emra Asfuroğlu Kalkan, Çağdaş Kalkan, Sezgin Barutcu, Orhan Küçükşahin, Özge Güçbey, Tankut Köseoğlu, Ateş Şendil, Mevlüt Hamamcı, Ersan Özaslan, İhsan Ateş, Emin Altıparmak, İrfan Soykan

Emra Asfuroğlu Kalkan
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Çağdaş Kalkan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Sezgin Barutcu
Department of Gastroenterology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
Orhan Küçükşahin
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Özge Güçbey
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Tankut Köseoğlu
The Departments of Gastroenterology Hacettepe University, Faculty of Pharmacy, Ankara
Ateş Şendil
Şendil?s Physical Therapy and Sports Medicine Center, Ankara, Turkey
Mevlüt Hamamcı
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Ersan Özaslan
Ankara Numune Hospital Department of Gastroenterology Clinic, Ankara
İhsan Ateş
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Emin Altıparmak
Department of Gastroenterology, Ankara Numune Educational and Research Hospital, Ankara, Turkey
İrfan Soykan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Asfuroğlu Kalkan, E., Kalkan, Çağdaş, Barutcu, S., Küçükşahin, O., Güçbey, Özge, Köseoğlu, T., … Soykan, İrfan. (2022). Prevalence and Determinants of Gastrointestinal Manifestations in Patients with Selected Rheumatologic Diseases. Turkish Journal of Gastroenterology, 33(7), 576–586. https://doi.org/10.5152/tjg.2022.21780
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Abstract

Background: Many rheumatic diseases may cause gastrointestinal manifestations. The goal of this study was to analyze the prevalence and predictors of gastrointestinal involvement in patients with rheumatic disorders. Methods: A retrospective chart review was performed for patients with systemic lupus erythematosus, rheumatoid arthritis, and sys- temic sclerosis who have consulted due to gastrointestinal symptoms. The relationship between clinical symptoms, gastroscopic/colo- noscopic findings, and histopathological results with current drugs and disease duration was evaluated. Results: A total of 364 patients with rheumatic disorders and 740 people as control group were included in the study. Abdominal bloating followed by abdominal pain, regurgitation, and heartburn were reported as the main complaints by more than half of the patients. Most of the patients had gastric mucosal changes expressed as Lanza score, and the presence of major polypharmacy was the most important factor affecting Lanza score (odds ratio: 10, 95% CI: 1.882-54.111, P < .007) followed by disease duration (odds ratio: 1.559, 95% CI: 1.369-1.775, P < .001) and age (odds ratio: 1.069, 95% CI: 1.030-1.109, P < .001). In general, approximately 30% of the patients were posi- tive for Helicobacter pylori infection and 35% showed intestinal metaplasia in histopathological examination. Most of the colonoscopic findings were associated with colonic polyps (n = 81). In multivariate analysis, disease duration was the only factor that affected the pres- ence of colonic lesions (Area Under the Receiver Operating Characteristic (ROC) Curve (AUROC): 0.871, 95% CI: 0.824-0.918, P < .001). Conclusion: Patients with rheumatologic diseases frequently have gastrointestinal manifestations. The most encountered gastrointes- tinal symptom was abdominal bloating, followed by abdominal pain. Being aware of gastrointestinal manifestations and their determi- nants may help physicians manage and follow patients with rheumatologic disorders.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 7
Pages 576-586
DOI 10.5152/tjg.2022.21780
History
Published Online July 15, 2022
Copyright
Copyright (c) 2022 Emra Asfuroğlu Kalkan, Çağdaş Kalkan, Sezgin Barutcu, Orhan Küçükşahin, Özge Güçbey, Tankut Köseoğlu, Ateş Şendil, Mevlüt Hamamcı, Ersan Özaslan, İhsan Ateş, Emin Altıparmak, İrfan Soykan
Affiliations
Emra Asfuroğlu Kalkan
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Çağdaş Kalkan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Sezgin Barutcu
Department of Gastroenterology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey
Orhan Küçükşahin
Department of Rheumatology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey
Özge Güçbey
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Tankut Köseoğlu
The Departments of Gastroenterology Hacettepe University, Faculty of Pharmacy, Ankara
Ateş Şendil
Şendil?s Physical Therapy and Sports Medicine Center, Ankara, Turkey
Mevlüt Hamamcı
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Ersan Özaslan
Ankara Numune Hospital Department of Gastroenterology Clinic, Ankara
İhsan Ateş
Department of Internal Medicine, Ministry of Health, Ankara City Hospital, Ankara, Turkey
Emin Altıparmak
Department of Gastroenterology, Ankara Numune Educational and Research Hospital, Ankara, Turkey
İrfan Soykan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Cite this Article
Asfuroğlu Kalkan, E., Kalkan, Çağdaş, Barutcu, S., Küçükşahin, O., Güçbey, Özge, Köseoğlu, T., … Soykan, İrfan. (2022). Prevalence and Determinants of Gastrointestinal Manifestations in Patients with Selected Rheumatologic Diseases. Turkish Journal of Gastroenterology, 33(7), 576–586. https://doi.org/10.5152/tjg.2022.21780
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