Original Article

The impact of direct-acting antiviral treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients: temporary? permanent?

Volume 31 · Issue 5 Publish Date: May 15, 2020
Osman Özdoğan Serkan Yaraş Fehmi Ateş Enver Üçbilek Orhan Sezgin Engin Altıntaş
Full Text PDF
DOI
Similar Articles

Published In

Turkish Journal of Gastroenterology

Volume 31 · Issue 5

Pages: 384-392

History

Published Online: May 15, 2020

Copyright © 2020 Osman Özdoğan, Serkan Yaraş, Fehmi Ateş, Enver Üçbilek, Orhan Sezgin, Engin Altıntaş

Osman Özdoğan
Department of Marmara University Institute of Gastroenterology, İstanbul
Serkan Yaraş
Department of Gastroenterology, State Hospital of Niğde, Niğde, Turkey
Fehmi Ateş
Departments of Gastroenterology, İnönü University, School of Medicine, Malatya
Enver Üçbilek
Department of Gastroenterology, Mersin University, School of Medicine, Mersin
Orhan Sezgin
Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey
Engin Altıntaş
Department of Gastroenterology, Mersin University, School of Medicine, Mersin
Özdoğan, O., Yaraş, S., Ateş, F., Üçbilek, E., Sezgin, O., & Altıntaş, E. (2020). The impact of direct-acting antiviral treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients: temporary? permanent?. Turkish Journal of Gastroenterology, 31(5), 384–392. https://doi.org/10.5152/tjg.2020.19273
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text Full Text PDF

Abstract

Background/Aims: In previous studies that investigated the impact of direct-acting antiviral (DAA) treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients have been compared to baseline values with either end of treatment or post-treatment values. The results are inconsistent. We evaluated patients throughout the treatment and after treatment. Materials and Methods: 121 patients were included in the study. 93 patients were treated with sofosbuvir/ledipasvir±Ribavirin (RBV), and 28 patients were treated with ombitasvir/paritaprevir/ritonavir+dasabuvir±RBV. Total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG) and homeostatic model assessment-insulin resistance (HOMA-IR) levels were measured at the onset of treatment, after the1st month of treatment, at the end of treatment, and 6 and 12 months after the end of treatment. Results: 117 patients were genotype 1. Sustained virological response was 98.4%. HOMA-IR values during treatment were significantly higher than at the beginning of treatment (p=0.0001). At 12 months there was a decrease in HOMA-IR, but this was not statistically significant (p=0.2048). TC and LDL levels were significantly increased in the first month of treatment (TC; 159±30, 180±34 mg/dl; LDL; 84±28, 100±30 mg/dl, respectively) (p<0.0001) and this increase was present during and after treatment. There was no statistically significant increase in TG (p=0120). Both treatment regimens showed similar effects on HOMA-IR, TC, and LDL. Conclusion: Patients with HCV treated with DAAs drugs showed increased IR, TC, and LDL cholesterol levels during treatment. After the end of treatment, IR goes back to normal, while the elevated TC and LDL levels persist indefinitely.

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 31 · Issue 5
Pages 384-392
DOI 10.5152/tjg.2020.19273
History
Published Online May 15, 2020
Copyright
Copyright (c) 2020 Osman Özdoğan, Serkan Yaraş, Fehmi Ateş, Enver Üçbilek, Orhan Sezgin, Engin Altıntaş
Affiliations
Osman Özdoğan
Department of Marmara University Institute of Gastroenterology, İstanbul
Serkan Yaraş
Department of Gastroenterology, State Hospital of Niğde, Niğde, Turkey
Fehmi Ateş
Departments of Gastroenterology, İnönü University, School of Medicine, Malatya
Enver Üçbilek
Department of Gastroenterology, Mersin University, School of Medicine, Mersin
Orhan Sezgin
Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey
Engin Altıntaş
Department of Gastroenterology, Mersin University, School of Medicine, Mersin
Cite this Article
Özdoğan, O., Yaraş, S., Ateş, F., Üçbilek, E., Sezgin, O., & Altıntaş, E. (2020). The impact of direct-acting antiviral treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients: temporary? permanent?. Turkish Journal of Gastroenterology, 31(5), 384–392. https://doi.org/10.5152/tjg.2020.19273
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines