Review

Usage of HCV viremic organs in liver transplantation to anti-HCV negative recipients: The current status and review of literature

Volume 30 · Issue 9 Publish Date: September 15, 2019
Aslı Çiftçibaşı Örmeci Çağla Yıldız Behnam Saberi Merve Gürakar Cem Şimşek Ahmet Gürakar
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Turkish Journal of Gastroenterology

Volume 30 · Issue 9

Pages: 771-775

History

Published Online: September 15, 2019

Copyright © 2019 Aslı Çiftçibaşı Örmeci, Çağla Yıldız, Behnam Saberi, Merve Gürakar, Cem Şimşek, Ahmet Gürakar

Aslı Çiftçibaşı Örmeci
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Çağla Yıldız
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Behnam Saberi
Division of Gastroenterology and Hepatology, Transplant Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.
Merve Gürakar
Princeton University, Program in Global Health and Health Policy, Princeton, USA
Cem Şimşek
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ahmet Gürakar
Division of Liver Transplantation Medicine/Hepatology, Nazih Zuhdi Transplantation Institute, Integris Baptist Medical Center, Oklahoma City, OK.
Çiftçibaşı Örmeci, A., Yıldız, Çağla, Saberi, B., Gürakar, M., Şimşek, C., & Gürakar, A. (2019). Usage of HCV viremic organs in liver transplantation to anti-HCV negative recipients: The current status and review of literature. Turkish Journal of Gastroenterology, 30(9), 771–775. https://doi.org/10.5152/tjg.2019.18656
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Abstract

Liver transplantation is the main curative therapy for end-stage liver disease. The number of transplanted organs is increasing globally. However, the number of available organs in the pool is insufficient, considering the excessive number of patients on the waiting list, which is a major concern for transplant programs. Hepatitis C infection (HCV) is a common indication for liver transplantation, and in recent years, a major progress has been made in its treatment with direct-acting antiviral (DAA) agents. HCV-positive livers have been transplanted to HCV-positive recipients for a long time. The high rate of sustained virologic response through DAA has brought new treatment options for the patients during the pre- and post-transplantation periods. Recently, there have been few reports of transplanting the available HCV-positive organs to HCV noninfected recipients. However, there is not yet an agreement on the optimal selection of patients who would benefit from such transplantation, and this has become a current topic of interest. Thus, we aim to review the current literature on this evolving topic.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 30 · Issue 9
Pages 771-775
DOI 10.5152/tjg.2019.18656
History
Published Online September 15, 2019
Copyright
Copyright (c) 2019 Aslı Çiftçibaşı Örmeci, Çağla Yıldız, Behnam Saberi, Merve Gürakar, Cem Şimşek, Ahmet Gürakar
Affiliations
Aslı Çiftçibaşı Örmeci
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Çağla Yıldız
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Behnam Saberi
Division of Gastroenterology and Hepatology, Transplant Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.
Merve Gürakar
Princeton University, Program in Global Health and Health Policy, Princeton, USA
Cem Şimşek
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ahmet Gürakar
Division of Liver Transplantation Medicine/Hepatology, Nazih Zuhdi Transplantation Institute, Integris Baptist Medical Center, Oklahoma City, OK.
Cite this Article
Çiftçibaşı Örmeci, A., Yıldız, Çağla, Saberi, B., Gürakar, M., Şimşek, C., & Gürakar, A. (2019). Usage of HCV viremic organs in liver transplantation to anti-HCV negative recipients: The current status and review of literature. Turkish Journal of Gastroenterology, 30(9), 771–775. https://doi.org/10.5152/tjg.2019.18656
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