Pediatric Gastroenterology - Original Article

A single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergy

Volume 29 · Issue 3 Publish Date: May 15, 2018
Zeren Barış Figen Özcay Özlem Yılmaz Özbek Nihan Haberal Faik Sarıalioğlu Mehmet Haberal
Full Text PDF
DOI

Published In

Turkish Journal of Gastroenterology

Volume 29 · Issue 3

Pages: 354-360

History

Published Online: May 15, 2018

Copyright © 2018 Zeren Barış, Figen Özcay, Özlem Yılmaz Özbek, Nihan Haberal, Faik Sarıalioğlu, Mehmet Haberal

Zeren Barış
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Başkent University School of Medicine, Ankara, Turkey
Figen Özcay
Department of Pediatric Gastroenterology, Başkent University Faculty of Medicine, Ankara, Turkey
Özlem Yılmaz Özbek
Department of Pediatric Allergy, Başkent University Hospital, Ankara, Turkey
Nihan Haberal
Department of Pathology, Başkent University Faculty of Medicine, Ankara
Faik Sarıalioğlu
Department of Pediatric Oncology, Başkent University Hospital, Ankara, Turkey
Mehmet Haberal
Division of General Surgery, Başkent University School of Medicine, Ankara, Turkey
Barış, Z., Özcay, F., Yılmaz Özbek, Özlem, Haberal, N., Sarıalioğlu, F., & Haberal, M. (2018). A single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergy. Turkish Journal of Gastroenterology, 29(3), 354–360. https://doi.org/10.5152/tjg.2018.17731
Endnote/Zotero/Mendeley (RIS) BibTeX
Full Text Full Text PDF

Abstract

Abstract Background/Aims: We evaluated our 16-year single-center experience of pediatric post-transplant lymphoproliferative disorder (PTLD) cases who underwent liver transplantation between 2001 and 2017. Materials and Methods: Of the 236 pediatric patients who underwent liver transplantation between 2001 and 2017, the clinical and laboratory data of eight patients diagnosed with PTLD were reviewed. The pre-transplant Epstein-Barr virus (EBV) status of 172 patients was also recorded. Results: The total incidence of PTLD was 3.4%. The incidence of PTLD was 10% in pre-transplant EBV immunoglobulin G (IgG)-seronegative patients and 0.8% in pre-transplant EBV IgG-seropositive patients. The mean age of the patients at liver transplantation was 2.71±3.21 years, and four patients were aged below 1 year at the time of transplantation. PTLD was diagnosed at 21.81±18.1 months after transplantation. The primary site of involvement was variable among patients: peripheral and mediastinal lymph nodes, stomach and intestine, transplanted graft, bone marrow, and nasopharynx. The eosinophil count varied greatly among patients, with a mean value of 524.62±679/mm3. Three patients had a food allergy and were administered an elimination diet at the time of PTLD diagnosis. Six patients had PTLD of B-cell origin. One patient died due to neutropenic sepsis during chemotherapy, whereas seven patients were followed up in full remission for 7.75±4 years. Conclusion: PTLD is a life-threatening complication of solid-organ transplantation with a heterogeneous clinical spectrum. Food allergy had a close association with PTLD. A close follow-up of patients with risk factors and an early diagnosis with appropriate treatment may lead to a better outcome. Cite this article as: Barış Z, Özçay F, Yılmaz Özbek Ö, Haberal N, Sarıalioğlu F, Haberal M. A single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergy. Turk J Gastroenterol 2018; 29: 354-60.

Most read articles by the same author(s)

1 2 > >> 
Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 29 · Issue 3
Pages 354-360
DOI 10.5152/tjg.2018.17731
History
Published Online May 15, 2018
Copyright
Copyright (c) 2018 Zeren Barış, Figen Özcay, Özlem Yılmaz Özbek, Nihan Haberal, Faik Sarıalioğlu, Mehmet Haberal
Affiliations
Zeren Barış
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Başkent University School of Medicine, Ankara, Turkey
Figen Özcay
Department of Pediatric Gastroenterology, Başkent University Faculty of Medicine, Ankara, Turkey
Özlem Yılmaz Özbek
Department of Pediatric Allergy, Başkent University Hospital, Ankara, Turkey
Nihan Haberal
Department of Pathology, Başkent University Faculty of Medicine, Ankara
Faik Sarıalioğlu
Department of Pediatric Oncology, Başkent University Hospital, Ankara, Turkey
Mehmet Haberal
Division of General Surgery, Başkent University School of Medicine, Ankara, Turkey
Cite this Article
Barış, Z., Özcay, F., Yılmaz Özbek, Özlem, Haberal, N., Sarıalioğlu, F., & Haberal, M. (2018). A single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergy. Turkish Journal of Gastroenterology, 29(3), 354–360. https://doi.org/10.5152/tjg.2018.17731
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX
Outlines