Original Article

Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with familial Mediterranean fever

Volume 26 · Issue 6 Publish Date: November 15, 2015
Mustafa Dinç Alpaslan Tanoğlu Yusuf Yazgan Yavuz Beyazıt Kemal Öncü Yalçın Önem Serdar Hıra Mustafa Kaplan İrfan Küçük Yusuf Serdar Sakın Levent Demirtürk
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Published In

Turkish Journal of Gastroenterology

Volume 26 · Issue 6

Pages: 487-491

History

Published Online: November 15, 2015

Copyright © 2015 Mustafa Dinç, Alpaslan Tanoğlu, Yusuf Yazgan, Yavuz Beyazıt, Kemal Öncü, Yalçın Önem, Serdar Hıra, Mustafa Kaplan, İrfan Küçük, Yusuf Serdar Sakın, Levent Demirtürk

Mustafa Dinç
Department of Internal Medicine, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Alpaslan Tanoğlu
Department of Gastroenterology, Sultan Abdulhamit Training and Research Hospital, İstanbul, Turkey
Yusuf Yazgan
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yavuz Beyazıt
Department of Gastroenterology, Çanakkale State Hospital, Çanakkale, Turkey
Kemal Öncü
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yalçın Önem
Department of Internal Medicine, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Serdar Hıra
Department of Biochemistry, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Mustafa Kaplan
Department of Gastroenterology, Sultan Abdulhamit Training and Research Hospital, İstanbul, Turkey
İrfan Küçük
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yusuf Serdar Sakın
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Levent Demirtürk
Department of Gastroenterology, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Dinç, M., Tanoğlu, A., Yazgan, Y., Beyazıt, Y., Öncü, K., Önem, Y., … Demirtürk, L. (2015). Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with familial Mediterranean fever. Turkish Journal of Gastroenterology, 26(6), 487–491. https://doi.org/10.5152/tjg.2015.0223
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Abstract

Abstract Background/Aims: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) are well-known inflammatory biomarkers, with a diagnostic potential for various diseases. The aim of the present study was to determine the potential diagnostic applications of serum MMP-9 and TIMP-1 concentrations in patients with familial Mediterranean fever (FMF). Materials and Methods: A total of 66 male FMF patients and 40 age-matched healthy subjects were included in this research. TIMP-1 and MMP-9 levels with conventional inflammation markers were determined. Pearson correlation analysis was used to determine the correlation between the characteristics of patients and the laboratory data. Results: In patients with FMF, serum MMP-9 levels and MMP-9/TIMP-1 ratios were found to be significantly elevated in both acute episode and asymptomatic periods (p=0.0001 and p=0.0001, respectively). There was no significant difference between TIMP-1 levels. A significant negative correlation between patients’ current age and TIMP-1 level in patients with acute episodes was detected (p=0.0008, r=−0.52). Moreover, a moderate negative correlation was noticed between erythrocyte sedimentation rate and TIMP-1 level in patients with acute episodes (p=0.01, r=−0.39). Additionally, a moderate negative correlation was found between the duration of colchicine use and MMP-9 and TIMP-1 levels during the attack period (p=0.04, r=−0.36 and p=0.02, r=−0.39, respectively). Conclusion: Our findings demonstrate that a significant MMP-9/TIMP-1 imbalance exists in patients with FMF, which reflects an ongoing inflammation in both FMF periods. Thus, the increased MMP-9 levels observed in FMF patients could rationalize therapeutic targeting to MMPs.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 6
Pages 487-491
DOI 10.5152/tjg.2015.0223
History
Published Online November 15, 2015
Copyright
Copyright (c) 2015 Mustafa Dinç, Alpaslan Tanoğlu, Yusuf Yazgan, Yavuz Beyazıt, Kemal Öncü, Yalçın Önem, Serdar Hıra, Mustafa Kaplan, İrfan Küçük, Yusuf Serdar Sakın, Levent Demirtürk
Affiliations
Mustafa Dinç
Department of Internal Medicine, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Alpaslan Tanoğlu
Department of Gastroenterology, Sultan Abdulhamit Training and Research Hospital, İstanbul, Turkey
Yusuf Yazgan
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yavuz Beyazıt
Department of Gastroenterology, Çanakkale State Hospital, Çanakkale, Turkey
Kemal Öncü
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yalçın Önem
Department of Internal Medicine, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Serdar Hıra
Department of Biochemistry, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Mustafa Kaplan
Department of Gastroenterology, Sultan Abdulhamit Training and Research Hospital, İstanbul, Turkey
İrfan Küçük
Department of Gastroenterology, Gülhane Military Medical Academy Haydarpaşa Training and Research Hospital, İstanbul, Turkey
Yusuf Serdar Sakın
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Levent Demirtürk
Department of Gastroenterology, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
Cite this Article
Dinç, M., Tanoğlu, A., Yazgan, Y., Beyazıt, Y., Öncü, K., Önem, Y., … Demirtürk, L. (2015). Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with familial Mediterranean fever. Turkish Journal of Gastroenterology, 26(6), 487–491. https://doi.org/10.5152/tjg.2015.0223
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