Original Article

Relationship between Helicobacter pylori infection and metabolic syndrome

Volume 26 · Issue 6 Publish Date: November 15, 2015
Emel Işıktaş Sayılar Bülent Çelik Şükrü Dumlu
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Published In

Turkish Journal of Gastroenterology

Volume 26 · Issue 6

Pages: 468-473

History

Published Online: November 15, 2015

Copyright © 2015 Emel Işıktaş Sayılar, Bülent Çelik, Şükrü Dumlu

Emel Işıktaş Sayılar
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
Bülent Çelik
Department of Statistics, Gazi University School of Sciences, Ankara, Turkey
Şükrü Dumlu
Department of Gastroenterology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
Işıktaş Sayılar, E., Çelik, B., & Dumlu, Şükrü. (2015). Relationship between Helicobacter pylori infection and metabolic syndrome. Turkish Journal of Gastroenterology, 26(6), 468–473. https://doi.org/10.5152/tjg.2015.0197
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Abstract

Abstract Background/Aims: To investigate the prevalence of metabolic syndrome (MS) and its components in patients with Helicobacter pylori that was detected using histopathological diagnostic methods. Materials and Methods: The study included 200 patients who presented with dyspeptic complaints and had indication for endoscopy. H. pylori-positive [HP (+)] and H. pylori-negative [HP (−)] patients were compared in terms of MS and its components. Results: The prevalence of H. pylori in general patient population is 49.5%. When patients were examined using a diagnostic criteria of MS, MS was present in 78 patients (78.8%) in the HP (+) (n=99) group and in 22 patients (21.8%) in the HP (−) (n=101) group (p<0.01). Logistic regression analysis revealed that H. pylori infection enhances the risk of developing MS by approximately 3.6 times (Relative Risk - (RR)=3.617, 95% CI: 2.465–5.307, p<0.001). With regard to the MS criteria, mean systolic–diastolic blood pressures and body mass index were significantly higher in HP (+) individuals than in HP (−) individuals. Furthermore, fasting plasma glucose, insulin and homeostatic model assessment–insulin resistance, very low-density lipoproteins, and triglyceride levels were also higher in the HP (+) group, whereas high-density lipoproteins levels were lower. Conclusion: H. pylori infection is a risk factor for MS. H. pylori leads to insulin resistance by developing chronic inflammation and accordingly facilitates the development of MS.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 6
Pages 468-473
DOI 10.5152/tjg.2015.0197
History
Published Online November 15, 2015
Copyright
Copyright (c) 2015 Emel Işıktaş Sayılar, Bülent Çelik, Şükrü Dumlu
Affiliations
Emel Işıktaş Sayılar
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
Bülent Çelik
Department of Statistics, Gazi University School of Sciences, Ankara, Turkey
Şükrü Dumlu
Department of Gastroenterology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
Cite this Article
Işıktaş Sayılar, E., Çelik, B., & Dumlu, Şükrü. (2015). Relationship between Helicobacter pylori infection and metabolic syndrome. Turkish Journal of Gastroenterology, 26(6), 468–473. https://doi.org/10.5152/tjg.2015.0197
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