Published In
Turkish Journal of Gastroenterology
Volume 26 · Issue 5
Pages: 386-391
History
Published Online: September 15, 2015
Copyright © 2015 Bala Başak Öven Ustaalioğlu, Metin Tilki, Zeynep Gamze Kılıçoğlu, Ahmet Bilici, Ali Sürmelioğlu, Recep Ustaalioğlu, Burçak Erkol
Bala Başak Öven Ustaalioğlu
Department of Medical Oncology and Pathology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul
Metin Tilki
Department of General Surgery, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Zeynep Gamze Kılıçoğlu
Department of Radiology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Ahmet Bilici
Department of Medical Oncology and Pathology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul
Ali Sürmelioğlu
Department of General Surgery, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Recep Ustaalioğlu
Department of Thoracic Surgery, Siyami Ersek Thoracic Surgery Hospital, İstanbul, Turkey
Burçak Erkol
Department of Medical Oncology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Öven Ustaalioğlu, B. B., Tilki, M., Kılıçoğlu, Z. G., Bilici, A., Sürmelioğlu, A., Ustaalioğlu, R., & Erkol, B. (2015). Prognostic markers for metastatic colon cancer patients undergoing multiple metastasectomies. Turkish Journal of Gastroenterology, 26(5), 386–391. https://doi.org/10.5152/tjg.2015.0169
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Abstract
Abstract Background/Aims: Following metastasis resection, 5-year survival rate has been reported as approximately 40%. There is no consensus regarding prognostic factors related to progression-free survival after repeated metastasectomies. Materials and Methods: A total of 21 patients with metastatic colorectal cancer who underwent repeated metastasectomies were retrospectively analyzed. The periods between the first and second metastasectomies and that between the second metastasectomy and progression were defined as metastasis-free survival 1 (MFS1) and metastasis-free survival 2 (MFS2), respectively. Univariate analysis was used to analyze factors related to MFS1 and MFS2. Results: Approximately two-thirds of the patients had synchronous metastasis, which were localized mostly in the liver (90%). During a 49-months follow-up, MFS1 was 15.7 (8.4–23) months and MFS2 was 26.3 (12.3–40.4) months. Systemic chemotherapy followed the first metastasectomy (p=0.01), and the recurrence site (p=0.03) was found to be related to MFS1. Furthermore, the number of metastases during the first metastasectomy (p=0.02), the type of the chemotherapy regimen administered following the first metastasectomy (p=0.04), and the number of metastases before the second metastasectomy (p=0.03) were significantly related to MFS2. Conclusion: Surgical resection is currently the most effective and curative form of therapy for colorectal metastasis, whenever possible. Repeated metastasectomies can be achieved safely in experienced centers; thus, the operability of the patients should be evaluated by a multidisciplinary approach during treatment.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 26 · Issue 5
Pages
386-391
History
Published Online
September 15, 2015
Copyright
Copyright (c) 2015 Bala Başak Öven Ustaalioğlu, Metin Tilki, Zeynep Gamze Kılıçoğlu, Ahmet Bilici, Ali Sürmelioğlu, Recep Ustaalioğlu, Burçak Erkol
Affiliations
Bala Başak Öven Ustaalioğlu
Department of Medical Oncology and Pathology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul
Metin Tilki
Department of General Surgery, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Zeynep Gamze Kılıçoğlu
Department of Radiology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Ahmet Bilici
Department of Medical Oncology and Pathology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul
Ali Sürmelioğlu
Department of General Surgery, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Recep Ustaalioğlu
Department of Thoracic Surgery, Siyami Ersek Thoracic Surgery Hospital, İstanbul, Turkey
Burçak Erkol
Department of Medical Oncology, Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey
Cite this Article
Öven Ustaalioğlu, B. B., Tilki, M., Kılıçoğlu, Z. G., Bilici, A., Sürmelioğlu, A., Ustaalioğlu, R., & Erkol, B. (2015). Prognostic markers for metastatic colon cancer patients undergoing multiple metastasectomies. Turkish Journal of Gastroenterology, 26(5), 386–391. https://doi.org/10.5152/tjg.2015.0169
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