Published In
Turkish Journal of Gastroenterology
Volume 26 · Issue 1
Pages: 20-24
History
Published Online: January 15, 2015
Copyright © 2015 Nazlı Demir, Emel Ahıshalı, Can Dolapçıoğlu, Şerif Ercan, Asuman Orçun Kaptanağası, Reşat Dabak, Nihal Yücel, Mehmet Sargın, Oya Uygur Bayramiçli
Nazlı Demir
Department of Internal Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Emel Ahıshalı
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Can Dolapçıoğlu
Departments of Gastroenterology, Lütfi Kırdar Kartal Education and Training Hospital, İstanbul
Şerif Ercan
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Asuman Orçun Kaptanağası
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Reşat Dabak
Department of Family Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Nihal Yücel
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Mehmet Sargın
Department of Family Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Oya Uygur Bayramiçli
Haydarpaşa Numune Hastanesi Gastroenteroloji Kliniği, İstanbul
Demir, N., Ahıshalı, E., Dolapçıoğlu, C., Ercan, Şerif, Orçun Kaptanağası, A., Dabak, R., … Uygur Bayramiçli, O. (2015). The relationship between serum adiponectin and resistin levels, insulin resistance and colorectal adenomas. Turkish Journal of Gastroenterology, 26(1), 20–24. https://doi.org/10.5152/tjg.2015.3626
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Abstract
Abstract Background/Aims: The relationship between adipocytokines and the development of colorectal cancer is well-documented. Our aim was to assess the relationship among serum adiponectin and resistin levels, insulin resistance, and colorectal adenoma to evaluate whether these parameters can be used as biomarkers to predict the development of colorectal adenoma. Materials and Methods: This is a cross-sectional case-control study conducted in 32 patients with colorectal adenoma and 30 control subjects. Serum adiponectin and resistin levels, body mass index values, waist and hip circumferences and Homeostasis Model Assessment scores were measured. Results: Resistin levels were slightly higher and adiponectin was slightly lower in patients with colorectal adenoma compared with controls; however, the differences in both parameters failed to reach statistical significance. The body mass index values and waist circumference of the patient group were significantly higher than controls (p=0.003 and p=0.002, respectively). Fasting serum insulin levels and Homeostasis Model Assessment scores of patients with colorectal adenoma were significantly higher than those of controls (p=0.02 and p=0.02, respectively). There was no relation between the number of colorectal adenomas and serum adiponectin or resistin levels. Conclusion: Our data indicate that obesity and insulin resistance may contribute to the development of colorectal adenoma and that serum adiponectin levels and insulin resistance may not have a substantial predictive value for colorectal adenoma.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 26 · Issue 1
Pages
20-24
History
Published Online
January 15, 2015
Copyright
Copyright (c) 2015 Nazlı Demir, Emel Ahıshalı, Can Dolapçıoğlu, Şerif Ercan, Asuman Orçun Kaptanağası, Reşat Dabak, Nihal Yücel, Mehmet Sargın, Oya Uygur Bayramiçli
Affiliations
Nazlı Demir
Department of Internal Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Emel Ahıshalı
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Can Dolapçıoğlu
Departments of Gastroenterology, Lütfi Kırdar Kartal Education and Training Hospital, İstanbul
Şerif Ercan
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Asuman Orçun Kaptanağası
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Reşat Dabak
Department of Family Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Nihal Yücel
Department of Biochemistry, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Mehmet Sargın
Department of Family Medicine, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey
Oya Uygur Bayramiçli
Haydarpaşa Numune Hastanesi Gastroenteroloji Kliniği, İstanbul
Cite this Article
Demir, N., Ahıshalı, E., Dolapçıoğlu, C., Ercan, Şerif, Orçun Kaptanağası, A., Dabak, R., … Uygur Bayramiçli, O. (2015). The relationship between serum adiponectin and resistin levels, insulin resistance and colorectal adenomas. Turkish Journal of Gastroenterology, 26(1), 20–24. https://doi.org/10.5152/tjg.2015.3626
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