Original Article

The change in microorganisms reproducing in bile and blood culture and antibiotic susceptibility over the years

Volume 25 · Issue 3 Publish Date: June 15, 2014
Nuretdin Suna Hakan Yıldız Mahmut Yüksel Erkan Parlak Selçuk Dişibeyaz Bülent Ödemiş Onur Aydınlı Zülfikar Bilge Serkan Torun Ayşe Yasemin Tezer Tekçe İsmail Taşkıran Nurgül Şaşmaz
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Published In

Turkish Journal of Gastroenterology

Volume 25 · Issue 3

Pages: 284-290

History

Published Online: June 15, 2014

Copyright © 2014 Nuretdin Suna, Hakan Yıldız, Mahmut Yüksel, Erkan Parlak, Selçuk Dişibeyaz, Bülent Ödemiş, Onur Aydınlı, Zülfikar Bilge, Serkan Torun, Ayşe Yasemin Tezer Tekçe, İsmail Taşkıran, Nurgül Şaşmaz

Nuretdin Suna
Department of Gastroenterology, Başkent University School of Medicine, Ankara, Turkey
Hakan Yıldız
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Mahmut Yüksel
Department of Gastroenterology, Türkiye Yüksek İhtisas University Hospital, Ankara, Turkey
Erkan Parlak
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Selçuk Dişibeyaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Bülent Ödemiş
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Onur Aydınlı
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Zülfikar Bilge
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Serkan Torun
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Ayşe Yasemin Tezer Tekçe
Department of Infection, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
İsmail Taşkıran
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Nurgül Şaşmaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Suna, N., Yıldız, H., Yüksel, M., Parlak, E., Dişibeyaz, S., Ödemiş, B., … Şaşmaz, N. (2014). The change in microorganisms reproducing in bile and blood culture and antibiotic susceptibility over the years. Turkish Journal of Gastroenterology, 25(3), 284–290. https://doi.org/10.5152/tjg.2014.6253
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Abstract

Abstract Background/Aims: Infection in the bile tract is a major cause of bacteremia and is related to high morbidity and mortality. We examined the changes in bacteria types and antibiotic susceptibility in bile cultures and simultaneous blood cultures taken from patients who applied for endoscopic retrograde cholangio pancreatography (ERCP)/percutaneous transhepatic cholangiography (PTC) for different bile duct diseases in recent years. Materials and Methods: Bacteria types that reproduce in bile and blood cultures from patients who applied for ERCP/PTC between the years of 2007 and 2012 in our clinic were examined. All patients were evaluated together, and in addition, the periods between 2007 and 2009 (Group 1) and between 2010 and 2012 (Group 2) were compared. Results: In total, 550 patients applied to this study. There were 266 patients in Group 1 and 284 in Group 2. Reproduction occurred in 77.6% of bile cultures. In the order of frequency, these cultures consisted of Escherichia coli (32.8%), Enterococcus spp. (26.2%), and Pseudomonas aeruginosa (11%). Enterococcus spp. were determined to be higher in Group 2 than Group 1 (p<0.016). Resistance to quinolones was found in 74.1% of patients, to ampicillin in 73.2%, and to cephalosporins in an average of 61%. Vancomycin was the most susceptible antibiotic (93.4%) to gram-positives. Resistance to piperacillin-tazobactam and amikacin was higher in Group 2 than Group 1 (p=0.001 and p=0.003, respectively). Conclusion: The most frequently reproducing bacteria in the bile cultures evaluated in our hospital were Escherichia coli and Enterococcus spp. Although it was thought that the antibiotics given empirically were effective against these bacteria, there was resistancerate of 75% in our study. We determined that the first- and second-step treatment protocols must be updated.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 3
Pages 284-290
DOI 10.5152/tjg.2014.6253
History
Published Online June 15, 2014
Copyright
Copyright (c) 2014 Nuretdin Suna, Hakan Yıldız, Mahmut Yüksel, Erkan Parlak, Selçuk Dişibeyaz, Bülent Ödemiş, Onur Aydınlı, Zülfikar Bilge, Serkan Torun, Ayşe Yasemin Tezer Tekçe, İsmail Taşkıran, Nurgül Şaşmaz
Affiliations
Nuretdin Suna
Department of Gastroenterology, Başkent University School of Medicine, Ankara, Turkey
Hakan Yıldız
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Mahmut Yüksel
Department of Gastroenterology, Türkiye Yüksek İhtisas University Hospital, Ankara, Turkey
Erkan Parlak
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Selçuk Dişibeyaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Bülent Ödemiş
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Onur Aydınlı
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Zülfikar Bilge
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Serkan Torun
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Ayşe Yasemin Tezer Tekçe
Department of Infection, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
İsmail Taşkıran
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Nurgül Şaşmaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Cite this Article
Suna, N., Yıldız, H., Yüksel, M., Parlak, E., Dişibeyaz, S., Ödemiş, B., … Şaşmaz, N. (2014). The change in microorganisms reproducing in bile and blood culture and antibiotic susceptibility over the years. Turkish Journal of Gastroenterology, 25(3), 284–290. https://doi.org/10.5152/tjg.2014.6253
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