Original Article

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

Volume 25 · Issue 1 Publish Date: February 15, 2014
Gülhan Akçil İbrahim Doğan Mustafa Cengiz Evren Doruk Engin Mehmet Doğan Selahattin Ünal Meltem Yalınay Çırak Ayşe Dursun
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Published In

Turkish Journal of Gastroenterology

Volume 25 · Issue 1

Pages: 81-85

History

Published Online: February 15, 2014

Copyright © 2014 Gülhan Akçil, İbrahim Doğan, Mustafa Cengiz, Evren Doruk Engin, Mehmet Doğan, Selahattin Ünal, Meltem Yalınay Çırak, Ayşe Dursun

Gülhan Akçil
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
İbrahim Doğan
Department of Gastroenterology, Gazi University School of Medicine, Ankara
Mustafa Cengiz
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey
Evren Doruk Engin
Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey
Mehmet Doğan
Departments of Pathology, Gazi University, Faculty of Medicine, Ankara
Selahattin Ünal
Gazi Üniversitesi Tıp Fakültesi Gastroenteroloji Anabilim Dalları, Ankara
Meltem Yalınay Çırak
Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey
Ayşe Dursun
Gaz, Üniversitesi Tıp Fakültesi Paroloji ABD New Orleans
Akçil, G., Doğan, İbrahim, Cengiz, M., Engin, E. D., Doğan, M., Ünal, S., … Dursun, A. (2014). The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease. Turkish Journal of Gastroenterology, 25(1), 81–85. https://doi.org/10.5152/tjg.2014.6512
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Abstract

Abstract Background/Aims: Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the Turkish population. Materials and Methods: A Total of 100 consecutive patients with GERD were enrolled in the study. Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed. Results: While thirty-two patients were diagnosed as esophagitis with varying severity the remaining patients had no esophagitis. Seventy six participants were positive for HP and the remaining patients were negative. The difference between erosive and non-erosive groups was statistically significant when we compared IL-1β (-511) but no difference regarding IL-1β (-31) and IL-1RN variations. We also analyzed T/T, C/T and C/C alleles and the difference was significant statistically in T/T allele between patients with and without erosive GERD 1 (3.1%) vs. 12 (17.9%), respectively with a p value <0.05. But C/C, C/T alleles of (-511), (-31) and IL-1RN polymorphisms were not statistically significant between the groups. Conclusion: IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 25 · Issue 1
Pages 81-85
DOI 10.5152/tjg.2014.6512
History
Published Online February 15, 2014
Copyright
Copyright (c) 2014 Gülhan Akçil, İbrahim Doğan, Mustafa Cengiz, Evren Doruk Engin, Mehmet Doğan, Selahattin Ünal, Meltem Yalınay Çırak, Ayşe Dursun
Affiliations
Gülhan Akçil
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
İbrahim Doğan
Department of Gastroenterology, Gazi University School of Medicine, Ankara
Mustafa Cengiz
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey
Evren Doruk Engin
Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey
Mehmet Doğan
Departments of Pathology, Gazi University, Faculty of Medicine, Ankara
Selahattin Ünal
Gazi Üniversitesi Tıp Fakültesi Gastroenteroloji Anabilim Dalları, Ankara
Meltem Yalınay Çırak
Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey
Ayşe Dursun
Gaz, Üniversitesi Tıp Fakültesi Paroloji ABD New Orleans
Cite this Article
Akçil, G., Doğan, İbrahim, Cengiz, M., Engin, E. D., Doğan, M., Ünal, S., … Dursun, A. (2014). The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease. Turkish Journal of Gastroenterology, 25(1), 81–85. https://doi.org/10.5152/tjg.2014.6512
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