E-ISSN 2148-5607
Pancreatobiliary - Original Article
Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis
1 Department of Gastroenterology, Harran University School of Medicine, Şanlıurfa, Turkey  
2 Department of Endocrinology and Metabolism, Harran University School of Medicine, Şanlıurfa, Turkey  
3 Department of Internal Medicine, Harran University School of Medicine, Şanlıurfa, Turkey  
4 Department of Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2019.18775
Key Words: Acute pancreatitis, thiol/disulfide, ischemia-modified albumin
Abstract

Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).

 

Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.

 

Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.

 

Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

 

Cite this article as: Uyanıkoğlu A, Sabuncu T, Yıldız R, Cindoğlu Ç, Kirmit A, Erel Ö. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol 2019; DOI: 10.5152/tjg.2019.18775

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