E-ISSN 2148-5607
Original Article
Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir
1 Department of Infectious Diseases and Clinical Microbiology, İstanbul Medipol University, İstanbul, Turkey  
2 Department of Infectious Diseases and Clinical Microbiology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey  
3 Department of Infectious Diseases and Clinical Microbiology, İstanbul Training and Research Hospital, İstanbul, Turkey  
4 Department of Pathology, İstanbul Training and Research Hospital, İstanbul, Turkey  
Turk J Gastroenterol 2016; 27: 42-46
DOI: 10.5152/tjg.2015.150348
Key Words: Entecavir, fatty liver, hepatitis B virus, tenofovir
Abstract

Background/Aims: We aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on viral kinetics and virologic response to tenofovir and entecavir treatment in patients with chronic hepatitis B virus (HBV) infection.

 

Materials and Methods: This study was designed as a retrospective multicenter cohort study. The impact of hepatosteatosis on pre-treatment serum HBV DNA levels and also on the virologic response to either tenofovir or entecavir at 6 and 12 months of therapy was investigated.

 

Results: A total of 145 cases were involved in the study [median age 40 (18–73) years, 90 (62%) males]. In multivariate analysis, it was detected that patients with NAFLD were older and had a higher body mass index (BMI) [Odds ratio (95% confidence interval) and p-value for age were 1.040 (1.003–1.079) and 0.033 and for BMI were 1.348 (1.190–1.528) and 0.0001, respectively]. When only the 43 patients who were younger than 35.5 years old and who had a BMI less than 27.59 were investigated, serum high-density lipoprotein (HDL) levels and serum HBV DNA levels were lower in patients with NAFLD in multivariate analysis [Odds ratio (95% confidence interval) and p-values for serum HDL level and HBV DNA level were 0.864 (0.061–0.980) and 0.023 and 0.995 (0.990–0.999) and 0.025, respectively]. Totally, 57 and 75 of the patients had received entecavir and tenofovir, respectively.

 

Conclusion: Viral replication decreases in patients with chronic HBV infection in the presence of NAFLD, and NAFLD had no impact on the virologic response to entecavir and tenofovir treatment. 

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