E-ISSN 2148-5607
Original Article
Incidence, causes, and outcomes of renal failure among cirrhotic patients
1 Department of Tropical Medicine and Gastroenterology, Sohag University Faculty of Medicine, Sohag, Egypt  
2 Department of Tropical Medicine and Gastroenterology, Assiut University Faculty of Medicine, Assiut, Egypt  
3 Department of Internal medicine, Assiut University Faculty of Medicine, Assiut, Egypt  
Turk J Gastroenterol 2015; 26: 517-521
DOI: 10.5152/tjg.2015.15169
Key Words: Renal failure, liver cirrhosis, hepatorenal syndrome, bacterial infection, parenchymal renal disease

Background/Aims: To evaluate the incidence, risk factors of RF among cirrhotic and its impact on patient’s outcome.


Materials and Methods: A total of 573 cirrhotic patients were evaluated for renal failure (RF) and its causes, 212 patients (37%) were enrolled. 


Results: Majority of the patients had post hepatitis C liver disease (n=190, 89.6%) with Child-Pugh score C (88.2%), HCC was in 21.2% of cases baseline characteristics. Infections were observed in 45.8% (n=97) of patients whereas, spontaneous bacterial peritonitis (SBP) was the most type of infection (19.3%) among cirrhotic patients with renal failure, followed by pneumonia (9.9%). Infection-induced represents 30.2% followed by hypovolemia (29.7%), whereas HRS was in 11.3%. Reversibility of the condition was seen in 81 patients (38.2%), whereas mortality was seen in 58 (27.4%) patients of RF. The reversibility was more common in the patients with infection, followed by hypovolemia. Mortality was higher in the patients with HRS followed by parenchymal renal disease.


Conclusion: Infection-induced and hypovolemic-induced RF represent the most common and also the most correctable causes and must be considered in management protocols for early detection and treatment that will serve for a better prognosis.

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