E-ISSN 2148-5607
Case Report
Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension
1 Department of Cardiology, Uludağ University Faculty of Medicine, Bursa, Turkey  
Turk J Gastroenterol 2014; 25: 429-432
DOI: 10.5152/tjg.2014.7688
Key Words: Portopulmonary hypertension, cirrhosis, liver transplantation, bosentan, sildenafil

Pulmonary arterial hypertension (PAH) that occurs in the setting of cirrhosis and portal hypertension is referred to as portopulmonary hypertension (PPHTN). Liver transplantation (LTx) is curative, but the presence of moderate-tosevere PPHTN may be a contraindication for transplantation because of the elevated risk of peri- and post transplantation morbidity and mortality. We report a successful liver transplantation in a patient with liver cirrhosis after treatment of moderate-to-severe PPHTN with a combination of the dual endothelin receptor antagonist bosentan and the specific phosphodiesterase-5 inhibitor sildenafil.

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