E-ISSN 2148-5607
Gastrointestinal Tract - Original Article
HLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey
1 Department of Gastroenterology, Şırnak State Hospital, Şırnak, Turkey  
2 Department of Gastroenterology, Eskişehir Osmangazi University, Eskişehir, Turkey  
3 Department of Hematology, Eskişehir Osmangazi University, Eskişehir, Turkey  
4 Department of Internal Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey  
5 Department of Gastroenterology, Konya Selçuk University, Konya, Turkey  
Turk J Gastroenterol 2019; 30: 321-325
DOI: 10.5152/tjg.2019.18255
Key Words: Celiac disease, HLA DQ2, HLA DQ8, Turkish population
Abstract

 

Background/Aims: Celiac disease is an autoimmune, familial disease that results in susceptibility to gluten in cereal and cereal products in genetically susceptible individuals. The aim of the present study was to investigate the presence of HLA-DQ2/DQ8 in patients with celiac disease, their first-degree relatives, and healthy community.

 

Materials and Methods: HLA-DQ2/DQ8 analysis was performed in adult patients with celiac disease ≥18 years old (94 patients), their first-degree relatives (89 people), and healthy group (102 individuals). Anemia, osteoporosis, and diarrhea were interrogated in the celiac patient group and also anti-tissue transglutaminase, anti-endomysium, and anti-gliadin antibodies were recorded.

 

Results: There was a significant relationship between HLA-DQ2/DQ8 presence in all groups, and the distribution of HLA-DQ2/DQ8 in all groups was different (p=0.000). No statistically significant correlation was found between the HLA tissue groups and diarrhea (p=0.087), osteoporosis (p=0.215), anemia (p=1.000), tissue transglutaminase antibodies (p=0.295), anti-gliadin antibodies (p=0.104), and anti-endomysium antibodies (p=0.243) in the celiac patient group.

 

Conclusion: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degree relatives.

 

Cite this article as: Özgenel ŞM, Temel T, Üsküdar Teke H, Yıldız P, Korkmaz H, Özakyol A. HLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey. Turk J Gastroenterol 2019; 30(4): 321-5.

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