Turkish Journal of Gastroenterology
Original Article

The relationship between serum histon levels and the severity of acute pancreatitis

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Department of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey

2.

-Department of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey;Department of Microbiology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey

Turk J Gastroenterol 0; 0: 0-0
DOI: 10.5152/tjg.2019.18592
Read: 489 Published: 25 July 2019

Abstract

Background/Aims: Despite various scoring systems and imaging methods, it is hard to predict the severity and the course of acute pancreatitis (AP) which necessitates better and more reliable markers. Since inflammation plays a key role in the pathogenesis of acute pancreatitis, we sought to determine whether histone which is a novel inflammatory marker may have a role in the prediction of severity and prognosis.

 

Materials and Methods: Eighty-eight consecutive adult patients (>18 years) with a first AP episode were prospectively enrolled in the study. Severe AP was defined as having a Revised Atlanta score greater than 3 in the first 48 h after admission. Circulating histone 3 and 4 levels were measured using ELISA method.

 

Results:  Eighty-eighty consecutive adult patients with a first episode of AP were divided into two groups according to the severity in which 56 were assigned to the mild-AP group (63.6 %) and 32 to the severe AP group (36.4%). White blood cell, hemoglobin, creatinine and aspartate aminotransferase levels were significantly higher in the severe AP group. However, there was no difference in serum histone levels between the groups and there was no correlation between Revised Atlanta score and serum histone levels either.

Conclusion: Serum histone levels did not significantly differ between the severe and mild AP groups. Therefore, these markers may not provide additional benefit for determining the severity of AP.

Cite this article as: Biberci Keskin E, İnce AT, Sümbül Gültepe B, Köker İH, Şentürk H. The relationship between serum histon levels and the severity of acute pancreatitis. Turk J Gastroenterol 2019; DOI: 10.5152/tjg.2019.18592

EISSN 2148-5607
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