Turkish Journal of Gastroenterology
Pancreatobiliary - Original Article

Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis

1.

Department of Gastroenterology, Harran University School of Medicine, Şanlıurfa, Turkey

2.

Department of Endocrinology and Metabolism, Harran University School of Medicine, Şanlıurfa, Turkey

3.

Department of Internal Medicine, Harran University School of Medicine, Şanlıurfa, Turkey

4.

Department of Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey

Turk J Gastroenterol 0; 0: 0-0
DOI: 10.5152/tjg.2019.18775
Read: 703 Downloads: 44 Published: 25 July 2019

Abstract

Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).

 

Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.

 

Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.

 

Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.

 

Cite this article as: Uyanıkoğlu A, Sabuncu T, Yıldız R, Cindoğlu Ç, Kirmit A, Erel Ö. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol 2019; DOI: 10.5152/tjg.2019.18775

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