ISSN 1300-4948 | E-ISSN 2148-5607
Original Article
HLA DQ2 and DQ8 frequency in adult coeliac patients, their first degree relatives and normal population in Turkey
1 Şırnak State Hospital, Specialist, Department of Gastroenterology  
2 Eskişehir Osmangazi University, Associate Professor, Department of Gastroenterology  
3 Eskişehir Osmangazi University, Associate Professor, Department of Hematology  
4 Eskişehir Osmangazi University, Associate Professor, Department of Internal Medicine  
5 Konya Selçuk University, Associate Professor, Department of Gastroenterology  
6 Eskişehir Osmangazi University, Professor, Department of Gastroenterology  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2018.18255
Key Words: Coeliac disease, HLA DQ2, HLA DQ8, Turkish population
Abstract

Background/Aims: Celiac disease is an autoimmune, familial disease that results in susceptibility to gluten in cereal and cereal products in genetically susceptible individuals. The aim of the present study was to investigate the presence of HLA-DQ2/DQ8 in patients with celiac disease, their first-degree relatives, and healthy community.


Materials and Methods
: HLA-DQ2/DQ8 analysis was performed in adult patients with celiac disease ≥18 years old (94 patients), their first-degree relatives (89 people), and healthy group (102 individuals). Anemia, osteoporosis, and diarrhea were interrogated in the celiac patient group and also anti-tissue transglutaminase, anti-endomysium, and anti-gliadin antibodies were recorded.


Results
: There was a significant relationship between HLA-DQ2/DQ8 presence in all groups, and the distribution of HLA-DQ2/DQ8 in all groups was different (p=0.000). No statistically significant correlation was found between the HLA tissue groups and diarrhea (p=0.087), osteoporosis (p=0.215), anemia (p=1.000), tissue transglutaminase antibodies (p=0.295), anti-gliadin antibodies (p=0.104), and anti-endomysium antibodies (p=0.243) in the celiac patient group.


Conclusion
: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degree relatives.

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AVES | Copyright © 2018 Turkish Society of Gastroenterology | Latest Update: 22.10.2018