ISSN 1300-4948 | E-ISSN 2148-5607
Basic & Translational - Original Article
Comparison of two porcine benign esophageal stricture models using radiofrequency ablation and endoscopic submucosal tunnel dissection
1 Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon; National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED), Incheon, South Korea  
2 National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED), Incheon; Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon, South Korea  
Turk J Gastroenterol 2018; 29: 502-508
DOI: 10.5152/tjg.2018.18046
Key Words: Stricture, esophageal, submucosal dissections, endoscopic, ablation, radiofrequency catheter
Abstract

Background/Aims: Large-animal benign esophageal stricture (BES) models are needed for the development of new endoscopic therapies and related devices. This study was undertaken to develop and compare swine BES models produced by radiofrequency ablation (RFA) or endoscopic submucosal tunnel dissection (ESTD).

 

Materials and Methods: RFA and ESTD were each performed on three pigs. Follow-up endoscopy and esophagography were performed immediately after the procedures and then 2, 3, and 4 weeks later. Four weeks after the procedures, all animals were sacrificed, and gross and histologic examinations were performed.

 

Results: BES was successfully achieved in both the RFA and ESTD groups, and all animals survived without any serious adverse events during the 4-week follow-up period. Mean procedural times were 9.3 min for RFA and 89.3 min for ESTD. ESTD caused long segment strictures whose average length was 4.5 cm, whereas RFA produced short strictures whose average length was 1.4 cm. BES began to form 2 weeks after both procedures. Degrees of strictures were similar at 3 and 4 weeks in the ESTD group; however, it started deteriorating over time in the RFA group. Histologic examinations showed that ESTD caused inflammation and fibrosis in the submucosal layer, whereas RFA induced extensive inflammation in the submucosal and muscularis propria layers.

 

Conclusion: BES was successfully achieved using RFA or ESTD in swine without serious complications. The methods have different characteristics; therefore, researchers should choose the method more appropriate for their purposes.

 

Cite this article as: Bang BW, Jeong S, Lee DH. Comparison of two porcine benign esophageal stricture models produced by radiofrequency ablation and endoscopic submucosal tunnel dissection. Turk J Gastroenterol 2018; 29: 502-8.

 

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