ISSN 1300-4948 | E-ISSN 2148-5607
Pancreatobiliary - Original Article
Dynamic thiol/disulphide homeostasis in acute pancreatitis
1 Department of Gastroenterology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
2 Department of Clinical Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
3 Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey  
4 Department of Gastroenterology, Çorlu State Hospital, Tekirdağ, Turkey  
Turk J Gastroenterol 2018; 29: 348-353
DOI: 10.5152/tjg.2018.17499
Key Words: Acute pancreatitis, disulphide bond, oxidative stress, thiol
Abstract

Background/Aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis.

Materials and Methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy volunteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups.

Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group; besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p<0.001).

Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the management of acute pancreatitis.

Cite this article as: Köseoğlu H, Alışık M, Başaran M, et al. Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turk J Gastroenterol 2018; 29: 348-53.

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