ISSN 1300-4948 | E-ISSN 2148-5607
Original Article
The results of positive proximal margin after resection for hilar cholangıocarcinoma: Analysis of 42 cases
1 Department of Gastroenterological Surgery, Türkiye High Training and Research Hospital, Ankara, Turkey  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2018.17752
Key Words: Klatskin’s tumor, frozen section, positive surgical margin, survival analysis
Abstract

 

Background/Aims: Hilar Cholangiocarcinoma (HC) is a tumor that invades the confluence of the left and right hepatic bile duct. Surgery is the definitive treatment but is also technically demanding. Here, we report our experience on 42 patients who underwent surgical resection for hilar cholangiocarcinoma. The aim of this study is to evaluate the margin status of resected specimens on frozen sections and impact of of R1 resection margin on survival.

 

Materials and Methods: Forty two patients with hilar cholangiocarcinoma who underwent surgical resection in our clinic between January 2008 and January 2017 are included in the study and patients charts are evaluated retrospectively

 

Results: The 1-, 2-, and 4-year overall survival of the 42 patients are 76.2%, 40%, and 10.7 %, respectively. Median survival of the patients with negative and positive proximal surgical margins are 22 (11.93-32.06 months) and 17 (14,43-19,56 months) months, respectively. No statistically significant difference is demonstrated between these two groups.

 

Conclusion: In HC surgery achieving negative proximal surgical margin is often very difficult. Our results demonstrate that frozen sectionsare reliable for the assessment of invasion status of the proximal and distal ductal surgical margin. Although complete resection is potentially curative, survival of patients with HC is still poor.  If there is no distant metastasis at the time of diagnosis, than extirpating surgery should be encouraged as survival of patients with positive and negative margins do not look significantly different.

 

Cite this article as: Öter V, Özer İ, Dalgıç T, Binarbaşı C, Ulaş M, Bostancı EB. The results of positive proximal margin after resection for hilar cholangıocarcinoma: Analysis of 42 cases. Turk J Gastroenterol 2018; 29: DOI: 10.5152/tjg.2018.17752

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AVES | Copyright © 2018 Turkish Society of Gastroenterology | Latest Update: 29.06.2018