E-ISSN 2148-5607
Role of gut microbiota: Obesity and NAFLD
1 Department of Gastroenterology, Bezmialem Vakif University Medical Faculty, İstanbul, Turkey  
Turk J Gastroenterol 2014; 25: 133-140
DOI: 10.5152/tjg.2014.7886
Key Words: Non-alcoholic fatty liver disease, obesity, endotoxin, microbiota

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts lipid metabolism from oxidation to de novo production. Furthermore, changes in intestinal barrier function contribute to metabolic endotoxemia in the form of low-grade microbial inflammation. Persistent inflammation exacerbates NAFLD progression. In this review, we discuss the role of gut microbiota in obesity and NAFLD. 

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