E-ISSN 2148-5607
Original Article
Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis
1 Department of Gastroenterology, Harran University School of Medicine, Şanlıurfa, Turkey  
2 Department of Endocrinology and Metabolism, Harran University School of Medicine, Şanlıurfa, Turkey  
3 Department of Internal Medicine, Harran University School of Medicine, Şanlıurfa, Turkey  
4 Department of Biochemistry, Harran University School of Medicine, Şanlıurfa, Turkey  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2019.18775
Key Words: Acute pancreatitis, thiol/disulfide, ischemia modified albumin
Abstract

 

Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) concentration between the patients with mild acute pancreatitis (AP) and healthy subjects.

 

Materials and Methods: Twenty-eight patients with AP and 35 age and sex matched healthy individuals were included in this study. Serum thiols/disulfide and IMA concentrations were measured and compared between the two groups.

 

Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001; and 273.3±76.8 vs. 346.9 ± 79 μmol/L, p<0.001, respectively). Disulfide (SS) levels were significantly higher in AP group than in the controls (24.2±11.1 μmol/L vs. 16.1 ± 9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) in both groups.

 

Conclusion: We found mild AP affectcts that serum thiols, disulfide levels, and thiol /disulfide balance.

 

Cite this article as: Uyanıkoğlu A, Sabuncu T, Yıldız R, Cindioğlu Ç, Kirmit A, Erel Ö. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol 2019; DOI: 10.5152/tjg.2019.18775

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