ISSN 1300-4948 | E-ISSN 2148-5607
Liver - Original Article
Screening for hepatic fibrosis and steatosis in Turkish patients with type 2 diabetes mellitus: A transient elastography study
1 Department of Internal Medicine, Marmara University School of Medicine, İstanbul, Turkey  
2 Department of Endocrinology and Metabolism, Marmara University School of Medicine; Department of Endocrinology and Metabolism, Koç University School of Medicine, İstanbul, Turkey  
3 Department of Gastroenterology, Marmara University School of Medicine; Institute of Gastroenterology, Marmara University, İstanbul, Turkey  
Turk J Gastroenterol ; : -
DOI: 10.5152/tjg.2018.18559
Key Words: Type 2 diabetes mellitus, non-alcoholic fatty liver disease, fibroscan, prevalence, obesity, metabolic syndrome
Abstract

Background/Aims: Non-alcoholic fatty liver disease is highly prevalent in patients with type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the potential usefulness of transient elastography (TE), which is a technique that allows measuring both fibrosis and liver fat content simultaneously, as a screening tool for hepatic involvement in Turkish patients with T2DM.


Materials and Methods
: We obtained liver stiffness measurements (LSMs, as a measure of fibrosis) and controlled attenuation parameter (CAP, as a marker of steatosis) in 124 (46 males and 78 females; mean body mass index (BMI): 33.2±6.6 kg/m2) Turkish patients with T2DM. The prevalence rates of overweight, obesity, and metabolic syndrome in our sample were 28.2%, 64.5%, and 77.4%, respectively. Probe-specific LSM cut-off values were used to define advanced fibrosis (≥F3) and cirrhosis (F4) (M probe: F3=9.6-11.4 kPa, F4 ≥11.5 kPa and XL probe: F3=9.3-10.9 kPa, F4 ≥11.0 kPa). Mild, moderate, and severe steatosis were defined as CAP 222-232 dB/m, CAP 233-289 dB/m, and CAP ≥290 dB/m, respectively.


Results
: Advanced fibrosis and cirrhosis were identified in 21 (16.9%) and 10 (8.0%) patients, respectively. TE-defined hepatic steatosis (CAP>222 dB/m) was detected in 117 (94.3%) patients. Mild, moderate, and severe steatosis were identified in 0, 29, and 88 patients, respectively.


Conclusion
: TE is a useful non-invasive imaging modality to screen for liver involvement in Turkish patients with T2DM. High rates of TE-defined fibrosis and steatosis in our sample reflect the presence of an elevated mean BMI.


Cite this article as
: Demir M, Deyneli O, Yılmaz Y. Screening for hepatic fibrosis and steatosis in Turkish patients with type 2 diabetes mellitus: A transient elastography study. Turk J Gastroenterol DOI: 10.5152/tjg.2018.18559

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AVES | Copyright © 2018 Turkish Society of Gastroenterology | Latest Update: 22.10.2018