ISSN 1300-4948 | E-ISSN 2148-5607
Gastrointestinal Tract - Original Article
Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey
1 Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey  
2 Department of Radiation Oncology, Hacettepe University Cancer Institute, Ankara, Turkey  
Turk J Gastroenterol 2018; 29: 411-418
DOI: 10.5152/tjg.2018.17660
Key Words: Anal cancer, squamous cell carcinoma, mitomycin, chemoradiation, human immunodeficiency virus
Abstract

Background/Aims: An organ preservation approach using chemoradiotherapy has been established for anal cancer. This retrospective cohort study aimed to define the clinico-demographic characteristics and outcomes of cases of human immunodeficiency virus (HIV)-negative anal carcinoma during a period of 20 years in a single comprehensive cancer institute.

Materials and Methods: This was a single-center retrospective cohort study of patients who were treated between January 1995 and January 2015. The primary outcome measures that were investigated included overall survival (OS), progression-free survival (PFS), colostomy rates, and colostomy-free survival (CFS).

Results: A total of 28 patients who were principally treated with standard 5-fluorouracil + mitomycin combination chemoradiotherapy were eligible for analysis. The 3- and 5-year PFS rates were 92.4% and 63%, respectively. The lower T stage was found to be associated with a prolonged PFS (p=0.001). The 3- and 5-year CFS rates were 84.3% and 74.9%, respectively. A longer CFS was observed with lower T stages (p=0.05). At the last follow-up, 75% of the patients with anal cancer were alive, and 71.4% of the patients were disease free. The median OS was not reached 

 

 

 

Cite this article as: Esin E, Yıldız F, Laçin Ş, et al. Real world survival data of a rare malignancy: Anal cancer results in HIV negative patients from Turkey. Turk J Gastroenterol 2018; 29: 411-8.

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AVES | Copyright © 2018 Turkish Society of Gastroenterology | Latest Update: 22.10.2018