ISSN 1300-4948 | E-ISSN 2148-5607
Case Report
Vildagliptin-induced acute pancreatitis without enzyme elevation
1 Department of Gastroenterology, Koç University School of Medicine, İstanbul, Turkey; Department of Gastroenterology, VKV American Hospital, İstanbul, Turkey  
2 Department of Radiology, VKV American Hospital, İstanbul, Turkey  
Turk J Gastroenterol 2017; 28: 514-517
DOI: 10.5152/tjg.2017.17308
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Key Words: Pancreatitis, vildagliptin, abdominal pain, diabetes, amylase, lipase
Abstract

We describe 2 patients with diabetes mellitus, presenting with upper abdominal pain. Although imaging findings were consistent with acute pancreatitis (AP), serum amylase and lipase levels were within normal limits. In both the cases, the only identifiable diagnostic culprit was vildagliptin. This is the first reported case of vildagliptin causing AP clinically and radiographically without elevated serum pancreatic enzymes. In conclusion, even when serum amylase and lipase levels are normal, AP should be kept in mind when making a differential diagnosis of patients with diabetes mellitus who present with abdominal pain and take dipeptidyl peptidase-4 (DPP-4) inhibitors. 

 

 

Cite this article as: Mungan Z, Attila T, Kabaoğlu ZÜ, Vural M. Vildagliptin-induced acute pancreatitis without enzyme elevation. Turk J Gastroenterol 2017. 2017; 28: 514-7.

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AVES | Copyright © 2017 Turkish Society of Gastroenterology | Latest Update: 13.11.2017