ISSN 1300-4948 | E-ISSN 2148-5607
Pediatric Gastroenterology - Original Article
Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease
1 Department of Pediatric Gastroenterology, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
2 Department of Pediatrics, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
3 Department of Radiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
4 Department of Biochemistry, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
5 Department of Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey  
Turk J Gastroenterol 2017; 28: 377-383
DOI: 10.5152/tjg.2017.17084
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Key Words: Non-alcoholic fatty liver disease, synbiotics, treatment, ethanol
Abstract

Background/Aims: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD).

 

Materials and Methods: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later.

 

Results: The grade of fatty liver was decreased (≥1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-α, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p<0.05 for all). We found that the median decrease in CRP (-0.16 vs. -0.03 mg/dL, p=0.003) and LDL levels (-17 vs. -3 mg/dL, p=0.019) were higher in patients who responded to the supplementation.

 

 

Conclusion: Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.

 

Cite this article as: Çakır M, İşbilen AA, Eyüpoğlu İ, et al. Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turk J Gastroenterol 2017; 28: 377-83

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