ISSN 1300-4948 | E-ISSN 2148-5607
Gastrointestinal Tract - Original Article
Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients
1 Department of Gastroenterology, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey  
2 Department of Molecular Biology and Genetics, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey  
3 Department of Molecular Medicine, İstanbul University Institute of Experimental Research, İstanbul, Turkey  
4 Department of Internal Medicine, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey  
Turk J Gastroenterol 2017; 28: 254-259
DOI: 10.5152/tjg.2017.17043
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Key Words: Ulcerative colitis, extracellular matrix protein 1 gene, single nucleotide polymorphism
Abstract

Background/Aims: Ulcerative colitis (UC) and Crohn’s disease are chronic inflammatory diseases. Genetic, immunologic, and microbial factors play an important role in their pathogenesis. Extracellular matrix protein 1 (ECM1), a gene related to mucosal barrier function, has been shown to be associated with UC. This study aims to determine the relationship between ECM1 gene rs3737240 single nucleotide polymorphism (SNP) and UC in a group of Turkish patients.

 

Materials and Methods: Ninety-four UC patients and 120 healthy controls were enrolled in the study. ECM1 gene rs3737240 SNP genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method.

 

Results: TT genotype was significantly more common in UC patients than in the healthy control group [p=0.034; odds ratio (OR) 2.34; 95% confidence interval (CI) 1.04-5.25]. The presence of C allele significantly lowered the UC risk (p=0.034; OR 0.42; 95% CI 0.19-0.95). TT genotype was significantly associated with azathioprine use in UC patients (p=0.037; OR 3.0; 95% CI 1.04-8.65). The C allele significantly reduced the probability of azathioprine use in UC patients (p=0.037; OR 0.33 CI 95% 0.11-0.96). No relation was found between rs3737240 SNP genotype and the phenotypical characteristics of UC patients.

 

Conclusion: The TT genotype of ECM1 gene rs3737240 SNP significantly increased susceptibility for UC and azathioprine use in UC patients in a Turkish population. 

 

Cite this article as: Adalı G, Tunalı NE, Yorulmaz E, et al. Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients. Turk J Gastroenterol 2017; 28: 254-9.

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